154026-93-4

• 常用中文名：瑞舒伐他汀中间体C-2
• 常用英文名：tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate
• CAS号：154026-93-4
• 分子式：C₁₀H₁₉ClO₄
• 分子量：238.708
• 发布时间：2018-07-14 14:58:23
• 更新时间：2026-07-14 22:02:33

名称

• 中文名: (3R,5S)-6-氯-3,5-二羟基己酸叔丁酯
• 英文名: tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate
• 中文别名: 瑞舒伐他汀中间体; 瑞舒伐他汀杂质; (3R,5S)-6-氯-3,5-二羟基己酸叔丁基酯; (3R,5S)6-氯-3,5-二羟基己酸叔丁酯(瑞舒伐他汀杂质); 瑞舒伐他汀相关化合物5
• 英文别名: (3R,5S)-6-Chloro-3,5-dihydroxyhexanoic acid 1,1-dimethylethyl ester; 6-chloro-3,5-dihydroxyhexanoic acid tert-butyl ester; 2-Methyl-2-propanyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate; Rosuvastatin Impurity 89; (3R,5S)-6-Chloro-3,5-dihydroxyhexanoic Acid tert-Butyl Ester; (3R,5S)-6-Chloro-3,5-dihydroxyhexanoic Acid tert-Butyl Ester (~); (3R,5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate (Rosuvastatin Impurity）; 154-4 C10H19ClO4 tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate; tert-Butyl 6-chloro-3,5-dihydroxyhexanoate; Hexanoic acid,6-chloro-3,5-dihydroxy-,1,1-dimethylethyl ester,(3R,5S); (3R,5S)-6-Chloro-3,5-dihydroxyhexanoic; 1,3-dimethyl-13-nitrosourea; 1,1-Dimethylethyl (3R,5S)-6-Chloro-3,5-dihydroxyhexanoate; ert-butyl(3R,5S)-6-chloro-3,5-dihydroxyhexanoate; Rosuvastatin Related Compound 5; Hexanoic acid, 6-chloro-3,5-dihydroxy-, 1,1-dimethylethyl es; t-butyl (3R,5S)-6-chloro-3,5-dihydroxy-3-hexanoate; (3R,5S)-6-Chloro-3,5-dihydroxyhexanoic A; (4R-Cis)-6-[(chlorite)methyl]-1,3-dihydrosy-4-Acetic acid,1,1-Dimethylethyl Ester; Hexanoic acid, 6-chloro-3,5-dihydroxy-, 1,1-diMethylethyl ester, (3R,5S); Rosuvastatin Impurity; (3R,5S)-tert-Butyl 6-chloro-3,5-dihydroxyhexanoate; 1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate; (3R,5S)-6-chloro-3,5-dihydroxyhexanoic acid tert-butyl ester; tert-butyl syn-(3R,5S)-6-chloro-3,5-dihydroxyhexanoate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 364.6±42.0 °C at 760 mmHg
• 分子式: C₁₀H₁₉ClO₄
• 分子量: 238.708
• 闪点: 174.3±27.9 °C
• 精确质量: 238.097183
• PSA: 66.76000
• LogP: 0.87
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.479

合成路线

276249-18-4 ~95% 154026-93-4

文献：PHOENIX CHEMICALS LIMITED Patent: WO2003/97569 A1, 2003 ; Location in patent: Page/Page column 13-16 ;

154026-92-3 ~% 154026-93-4

文献：Wolberg, Michael; Hummel, Werner; Mueller, Michael Chemistry - A European Journal, 2001 , vol. 7, # 21 p. 4562 - 4571

1694-31-1 ~% 154026-93-4

文献：Wolberg, Michael; Hummel, Werner; Mueller, Michael Chemistry - A European Journal, 2001 , vol. 7, # 21 p. 4562 - 4571

上下游产品

上游产品  3
276249-18-4 154026-92-3 1694-31-1
下游产品  1
154026-94-5