110283-79-9

• 常用中文名：CI-966
• 常用英文名：CI-966
• CAS号：110283-79-9
• 分子式：C₂₃H₂₁F₆NO₃
• 分子量：473.40800
• 发布时间：2016-04-27 23:42:25
• 更新时间：2025-08-24 09:00:15
• CI-966 (PD 126141) is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.

名称

• 英文名: 1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
• 英文别名: 1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-3-pyridine carboxylic acid; 1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid; CI-966; 1,2,5,6-tetrahydro-1-<2-<bis<4-(trifluoromethyl)phenyl>methoxy>ethyl>-3-pyridinecarboxylic acid; 3-Pyridinecarboxylicacid,1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro; Tocris-1296

物化性质

• 密度: 1.34g/cm3
• 沸点: 514.1ºC at 760mmHg
• 分子式: C₂₃H₂₁F₆NO₃
• 分子量: 473.40800
• 闪点: 264.7ºC
• 精确质量: 473.14300
• PSA: 49.77000
• LogP: 5.48480
• 蒸汽压: 2.16E-11mmHg at 25°C
• 折射率: 1.517
• 储存条件: 2-8°C，密封，干燥

合成路线

132284-15-2 ~% 110283-79-9

文献：Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248

455-19-6 ~% 110283-79-9

文献：Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248

402-43-7 ~% 110283-79-9

文献：Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248

22543-52-8 ~% 110283-79-9

文献：Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248

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