135949-60-9

• 常用中文名：RB-101
• 常用英文名：RB-101
• CAS号：135949-60-9
• 分子式：C₃₁H₃₈N₂O₃S₃
• 分子量：582.84000
• 发布时间：2017-01-24 22:48:33
• 更新时间：2025-08-26 10:54:07
• RB-101 is an mixed enkephalinase inhibitor that inhibits Aminopeptidase N and Neutral Endopeptidase with IC50 of 11 nM and 2 nM, respectively.

名称

• 英文名: benzyl (2S)-2-[[2-[[[(2S)-2-amino-4-methylsulfanylbutyl]disulfanyl]methyl]-3-phenylpropanoyl]amino]-3-phenylpropanoate
• 英文别名: N-(2-Benzyl-3-((2-amino-4-methylthio)butyl dithio)-1-oxopropyl)phenylalanine benzyl ester; C31H38N2O3S3; RB 101; L-Phenylalanine,N-(2-(((2-amino-4-(methylthio)butyl)dithio)methyl)-1-oxo-3-phenylpropyl)-,phenylmethyl ester

物化性质

• 密度: 1.21g/cm3
• 沸点: 757.5ºC at 760 mmHg
• 分子式: C₃₁H₃₈N₂O₃S₃
• 分子量: 582.84000
• 闪点: 411.9ºC
• 精确质量: 582.20400
• PSA: 160.81000
• LogP: 7.31860
• 蒸汽压: 7.74E-23mmHg at 25°C
• 折射率: 1.617

合成路线

141437-98-1 ~71% 135949-60-9

文献：Fournie-Zaluski, Marie-Claude; Coric, Pascal; Turcaud, Serge; Lucas, Evelyne; Noble, Florence; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2473 - 2481

141437-94-7 ~% 135949-60-9

文献：Fournie-Zaluski, Marie-Claude; Coric, Pascal; Turcaud, Serge; Lucas, Evelyne; Noble, Florence; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2473 - 2481

139429-04-2 ~% 135949-60-9

文献：Fournie-Zaluski, Marie-Claude; Coric, Pascal; Turcaud, Serge; Lucas, Evelyne; Noble, Florence; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2473 - 2481

141437-96-9 ~% 135949-60-9

文献：Fournie-Zaluski, Marie-Claude; Coric, Pascal; Turcaud, Serge; Lucas, Evelyne; Noble, Florence; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2473 - 2481

141437-97-0 ~% 135949-60-9

文献：Fournie-Zaluski, Marie-Claude; Coric, Pascal; Turcaud, Serge; Lucas, Evelyne; Noble, Florence; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2473 - 2481

135949-97-2 ~% 135949-60-9

文献：Fournie-Zaluski, Marie-Claude; Coric, Pascal; Turcaud, Serge; Lucas, Evelyne; Noble, Florence; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2473 - 2481