426219-18-3

• 常用中文名：6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺
• 常用英文名：TAK-700 (Orteronel)
• CAS号：426219-18-3
• 分子式：C₁₈H₁₇N₃O₂
• 分子量：307.346
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) P450 (e.g. CYP17) 抑制剂
• 发布时间：2018-12-27 17:05:38
• 更新时间：2024-01-03 11:49:41
• Orteronel (racemic) is a mixture of S-Orteronel and R-Orteronel isomers. Orteronel, aslo known as TAK-700, is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells.

名称

• 中文名: 6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺
• 英文名: 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide
• 英文别名: 6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide; S1195_Selleck; 2-Naphthalenecarboxamide, 6-(6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-; TAK700; (S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-e]imidazol-7-yl)-N-methyl-2-naphthamide; TAK-700 (Orteronel); 6-[7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthamide; Orteronel; TAK-700

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 685.1±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 分子量: 307.346
• 闪点: 368.2±28.7 °C
• 精确质量: 307.132080
• PSA: 67.15000
• LogP: -0.13
• 外观性状: 粉末
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.695
• 储存条件: -20℃

合成路线

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566200-77-9 74-89-5 426219-35-4 426219-43-4
109-72-8 5773-80-8 426219-46-7 1346155-54-1
426219-47-8
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