19171-18-7

• 常用中文名：4-硝基沙利度胺
• 常用英文名：4-Nitrothalidomide
• CAS号：19171-18-7
• 分子式：C₁₃H₉N₃O₆
• 分子量：303.227
• 发布时间：2018-06-22 17:57:06
• 更新时间：2024-01-02 16:13:23

名称

• 中文名: 1,3-二氧-2-( 2,6-二氧哌啶-3-基) -5-硝基异二氢吲哚
• 英文名: 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindole-1,3-dione
• 中文别名: 泊马度胺中间体; 4-硝基沙利度胺
• 英文别名: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-nitro-isoindoline; 2-(2,6-dioxo-piperidin-3-yl)-4-nitro-isoindole-1,3-dione; 3-(1',3'-Dioxo-4'-nitroisoindolinyl-2')-2,6-dioxopiperidine; 2-(2,6-dioxopiperidin-3-yl)-4-nitro-1H-isoindole-1,3(2H)-dione; 4-Nitrothalidomide; 2-(2,6-dioxopiperidine-3-yl)-4-nitrophthalimide; 3-Nitrothalidomide; N-(2,6-Dioxo-3-piperidyl)-3-nitrophthalimide; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-nitro-; 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione; Phthalimide,N-(2,6-dioxo-3-piperidyl)-3-nitro; 2-(2,6-Dioxo-3-piperidinyl)-4-nitro-1H-isoindole-1,3(2H)-dione; Pomalidomide Impurity 6

物化性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 603.4±50.0 °C at 760 mmHg
• 分子式: C₁₃H₉N₃O₆
• 分子量: 303.227
• 闪点: 318.7±30.1 °C
• 精确质量: 303.049133
• PSA: 132.86000
• LogP: 0.27
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.674
• 储存条件: 室温，保存在惰性气体中

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TI4930000 CHEMICAL NAME : Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-nitro- CAS REGISTRY NUMBER : 19171-18-7 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C13-H9-N2-O6 MOLECULAR WEIGHT : 289.24 WISWESSER LINE NOTATION : T56 BVNVJ FNW C- DT6VMVTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 900 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,987,1964

安全

• 海关编码: 2925190090

合成路线

2650-64-8 ~% 19171-18-7

文献：Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630

24666-55-5 ~% 19171-18-7

文献：Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630

641-70-3 24666-56-6 ~% 19171-18-7

文献：Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630

641-70-3 2353-44-8 ~% 19171-18-7

文献：Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881

上下游产品

上游产品  5
2650-64-8 24666-55-5 641-70-3 24666-56-6
2353-44-8
下游产品  1
19171-19-8

海关

海关编码	2925190090
中文概述	2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%