Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application

C Contino-Pépin, A Parat, S Périno, C Lenoir…

文献索引：Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881

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被引用次数: 13

摘要

The present work deals with the synthesis of a new series of thalidomide derivatives for therapeutic applications. These compounds were evaluated in vitro on a human endothelial cell line EA. hy926 for their antiproliferative potential and in vivo on an experimental animal multiple sclerosis model called EAE as angiogenesis inhibitors. The preliminary results obtained on EAE assays seem to validate that anti-angiogenesis compounds could be ...