21721-92-6

• 常用中文名：硝法唑
• 常用英文名：Nitrefazole
• CAS号：21721-92-6
• 分子式：C₁₀H₈N₄O₄
• 分子量：248.19500
• 相关类别： 信号通路 代谢酶/蛋白酶 醛脱氢酶(ALDH)
• 发布时间：2018-07-12 11:19:53
• 更新时间：2024-01-10 15:15:20
• 硝基咪唑是一种4-硝基咪唑衍生物,对参与酒精代谢的乙醛脱氢酶(ALDH)具有强烈而持久的抑制作用。

名称

• 中文名: 硝法唑
• 英文名: 2-methyl-4-nitro-1-(4-nitrophenyl)imidazole
• 中文别名: 1-(4-硝基苯基)-2-甲基-4-硝基咪唑
• 英文别名: Nitrefazol [INN-Spanish]; 2-methyl-4-nitro-1-(4-nitro-phenyl)-1H-imidazole; 1-(p-nitrophenyl)-2-methyl-4-nitroimidazole; Nitrefazolum [INN-Latin]; EINECS 244-542-8; BT-985; Nitrefazole; 2-Methyl-4-nitro-1-(4-nitrophenyl)imidazol; Altimol; EMD-15,700; nitrefazol; 1-(4-nitrophenyl)-2-methyl-4-nitroimidazole

物化性质

• 密度: 1.53g/cm3
• 沸点: 484.9ºC at 760 mmHg
• 分子式: C₁₀H₈N₄O₄
• 分子量: 248.19500
• 闪点: 247.1ºC
• 精确质量: 248.05500
• PSA: 109.46000
• LogP: 3.04350
• 蒸汽压: 1.48E-09mmHg at 25°C
• 折射率: 1.686

生物活性

• 描述: 硝基咪唑是一种4-硝基咪唑衍生物,对参与酒精代谢的乙醛脱氢酶(ALDH)具有强烈而持久的抑制作用。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 醛脱氢酶(ALDH)
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Koda LY, Madamba SG, Bloom FE. Hypotensive response of ethanol in rats pretreated with disulfiram or nitrefazole. Life Sci. 1984;35(16):1659-1665.

  [2]. Zorzano A, Herrera E. Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes. Biochem Pharmacol. 1990;39(5):873-878.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI7615000 CHEMICAL NAME : Imidazole, 2-methyl-4-nitro-1-(p-nitrophenyl)- CAS REGISTRY NUMBER : 21721-92-6 BEILSTEIN REFERENCE NO. : 0546441 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C10-H8-N4-O4 MOLECULAR WEIGHT : 248.22 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4813 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1119 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5501 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1475 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >6400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 1845 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

安全

• 海关编码: 2933290090

合成路线

73225-15-7 ~% 21722-04-3 21721-92-6

文献：Klink; Pachler; Gottschlich Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 8 p. 1220 - 1222

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海关

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%