CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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EJ9980000
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CHEMICAL NAME :
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Butanedioic acid, mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano( 4,3-j)-1,2- benzodioxepin-10-yl)ester, sodium salt, (3R-(3-alpha,5a-beta,6-beta,8a-beta,9-alpha,10- alpha,12-beta,12aR*))-
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CAS REGISTRY NUMBER :
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82864-68-4
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LAST UPDATED :
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199503
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C19-H27-O8.Na
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MOLECULAR WEIGHT :
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406.45
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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438 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3 Volume(issue)/page/year: 13,234,1988
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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520 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine) V.1- 1981- Volume(issue)/page/year: 2,99,1982
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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475 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine) V.1- 1981- Volume(issue)/page/year: 2,99,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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630 mg/kg/14D-I
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TOXIC EFFECTS :
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Cardiac - EKG changes not diagnostic of specified effects Blood - changes in bone marrow (not otherwise specified) Blood - changes in other cell count (unspecified)
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REFERENCE :
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ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 1,135,1987 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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5400 ug/kg
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SEX/DURATION :
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female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3 Volume(issue)/page/year: 13,234,1988
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