138452-21-8

• 常用中文名：盐酸非索非那定
• 常用英文名：Fexofenadine
• CAS号：138452-21-8
• 分子式：C₃₂H₄₀ClNO₄
• 分子量：538.117
• 发布时间：2018-02-28 08:00:00
• 更新时间：2024-01-02 22:31:23
• 下载msds

名称

• 中文名: 盐酸非索非那定
• 英文名: fexofenadine hydrochloride
• 英文别名: 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropansäurehydrochlorid; Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1); Fexofenadine HCl; Fexofenadine hydrochloride; benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride; feudomycinone A; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1); acide 2-[4-(1-hydroxy-4-{4-[hydroxy(diphényl)méthyl]pipéridin-1-yl}butyl)phényl]-2-méthylpropanoïque chlorhydrate; UNII:2S068B75ZU; 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1); 13-Desoxodaunomycinon; benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-, hydrochloride (1:1)

物化性质

• 沸点: 697.3ºC at 760 mmHg
• 熔点: 195.0 - 199.0ºC
• 分子式: C₃₂H₄₀ClNO₄
• 分子量: 538.117
• 闪点: 375.5ºC
• 精确质量: 537.264587
• PSA: 81.00000
• LogP: 6.25040
• 外观性状: 白色结晶粉末
• 储存条件: -20°C， 密封， 干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

合成路线

83799-24-0 ~88% 138452-21-8

文献：WO2011/158262 A1, ; Page/Page column 13 ;

76811-98-8 ~% 138452-21-8

文献：US2005/282860 A1, ; Page/Page column 3 ;

847360-76-3 ~% 138452-21-8

文献：WO2005/19175 A1, ; Page/Page column 28 ;

847360-77-4 ~% 138452-21-8

文献：WO2005/19175 A1, ; Page/Page column 28 ;

76812-02-7 ~99% 138452-21-8

文献：EP1178041 A1, ; Page 9-10 ;

154825-96-4 ~% 138452-21-8

文献：WO2004/43922 A1, ; Page 8 - 9 ;

1133879-72-7 ~% 138452-21-8

文献：WO2009/34582 A2, ; Page/Page column 9 ;

154825-95-3 ~% 138452-21-8

文献：WO2011/158262 A1, ;

1352802-40-4 ~% 138452-21-8

文献：WO2011/158262 A1, ;

上下游产品

上游产品  7
83799-24-0 76811-98-8 847360-76-3 847360-77-4
154825-96-4 1133879-72-7 154825-95-3
下游产品  1
83799-24-0

海关

海关编码	2942000000