CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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NJ5098950
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CHEMICAL NAME :
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1H-Imidazo(1,2-b)pyrazole, 2,3-dihydro-
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CAS REGISTRY NUMBER :
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6714-29-0
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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12
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MOLECULAR FORMULA :
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C5-H7-N3
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MOLECULAR WEIGHT :
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109.15
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WISWESSER LINE NOTATION :
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T55 ANN FM&TJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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410 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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993 mg/kg
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TOXIC EFFECTS :
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Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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400 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Behavioral - ataxia Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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500 mg/kg/5D-I
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Blood - normocytic anemia
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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500 mg/kg/10D-I
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TOXIC EFFECTS :
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Blood - changes in erythrocyte (RBC) count
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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415 mg/kg/5D-I
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TOXIC EFFECTS :
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Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Blood - hemorrhage
MUTATION DATA
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TYPE OF TEST :
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DNA inhibition
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TEST SYSTEM :
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Rodent - mouse Ascites tumor
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DOSE/DURATION :
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600 mg/kg
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REFERENCE :
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BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 20,2639,1971
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