14080-59-2

• 常用中文名：4-氯噻吩[2,3-D]嘧啶
• 常用英文名：4-Chlorothieno[2,3-d]pyrimidine
• CAS号：14080-59-2
• 分子式：C₆H₃ClN₂S
• 分子量：170.619
• 相关类别： 医药中间体 杂环化合物 嘧啶类化合物 噻吩嘧啶
• 发布时间：2018-02-13 08:00:00
• 更新时间：2024-01-02 09:44:28
• 下载msds

名称

• 中文名: 4-氯噻吩[2,3-D]嘧啶
• 英文名: 4-Chlorothieno[2,3-d]pyrimidine
• 中文别名: 4-氯噻吩并[2,3-D]嘧啶; 4-氯噻吩[2,3-d]嘧啶; 4-氯-二噻酚并[2,3-D]嘧啶
• 英文别名: Thieno[2,3-d]pyrimidine, 4-chloro-; 4-Chlorothieno[2,3-d]pyrimidine; MFCD01312373

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 285.7±20.0 °C at 760 mmHg
• 熔点: 109-113ºC
• 分子式: C₆H₃ClN₂S
• 分子量: 170.619
• 闪点: 126.6±21.8 °C
• 精确质量: 169.970551
• PSA: 54.02000
• LogP: 1.79
• 外观性状: 淡黄色固体
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.710
• 储存条件: 2-8°C

MSDS

Name: 4-Chlorothieno[2 3-d]pyrimidine Material Safety Data Sheet Synonym: None Known CAS: 14080-59-2 Section 1 - Chemical Product MSDS Name:4-Chlorothieno[2 3-d]pyrimidine Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 14080-59-2 4-Chlorothieno[2,3-d]pyrimidine 100 unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store under an inert atmosphere. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 14080-59-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: pale yellow Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 104.4-106.5 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C6H3N2ClS Molecular Weight: 170.623 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Oxidizing agents, alcohols, amines, bases. Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 14080-59-2 unlisted. LD50/LC50: Not available. Carcinogenicity: 4-Chlorothieno[2,3-d]pyrimidine - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 6 Keep under nitrogen. S 22 Do not breathe dust. S 24/25 Avoid contact with skin and eyes. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 14080-59-2: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 14080-59-2 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 14080-59-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 25-36
• 安全声明 (欧洲): 26-45
• 海关编码: 2934999090

合成路线

14080-50-3 ~97% 14080-59-2

文献：Katholieke Universiteit Leuven, K.U. Leuven RandD; Herman, Jean; Louat, Thierry Patent: US2014/88088 A1, 2014 ; Location in patent: Paragraph 1228-1230 ;

75-09-2 14080-50-3 ~99% 14080-59-2

文献：Warner-Lambert Company Patent: US5654307 A1, 1997 ; US 5654307 A

79-37-8 14080-50-3 ~97% 14080-59-2

文献：KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN RandD; De Jonghe, Steven; Gao, Ling-Jie; Herdewijn, Piet; Herman, Jean; Jang, Miyeon; Leyssen, Pieter; Louat, Thierry; Neyts, Johan; Pannecouque, Christophe; Vanderhoydonck, Bart Patent: US2013/190297 A1, 2013 ; Location in patent: Paragraph 1213; 1214; 1215 ;

4651-82-5 ~% 14080-59-2

文献：Tetrahedron Letters, , vol. 48, # 30 p. 5261 - 5264

55654-21-2 ~% 14080-59-2

文献：Tetrahedron Letters, , vol. 48, # 30 p. 5261 - 5264

上下游产品

上游产品  5
14080-50-3 75-09-2 79-37-8 4651-82-5
55654-21-2
下游产品  10
18740-26-6 272-24-2 1217309-72-2 56844-12-3
14080-55-8 14080-56-9 14080-52-5 86825-96-9
60703-80-2 63893-52-7

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%