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53518-15-3生产厂家

53518-15-3价格

相关CAS号：
53518-15-3 201608-14-2
41934-47-8 53518-14-2
52840-38-7 575-03-1
26093-31-2 113721-87-2
575-04-2 115453-82-2

53518-15-3

53518-15-3结构式
53518-15-3结构式
  • 常用中文名：7-氨基-4-三氟甲基香豆素
  • 常用英文名：coumarin 151
  • CAS号：53518-15-3
  • 分子式：C10H6F3NO2
  • 分子量：229.155
  • 相关类别： 染料试剂
  • 发布时间：2018-02-15 08:00:00
  • 更新时间：2024-01-02 23:41:45
  • 7-Amino-4-(trifluoromethyl)coumarin (AFC, Coumarin 151) 是荧光标记物,可用来灵敏的检测蛋白酶。它的激发和发射波长分别为400和500 nm。

化源商城直购

中文名 香豆素 151
英文名 coumarin 151
中文别名 7-氨基-4-氟甲醇
7-氨基-4-(三氟甲基)香豆素
7-氨基-4-三氟甲基香豆素
香豆素490
英文别名 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one
2H-1-Benzopyran-2-one, 7-amino-4- (trifluoromethyl)-
7-amino-4-trifluoromethylchromen-2-one
MFCD00006858
Coumarin 151
7-NH2-4-CF3-coumarin
7-Amino-4-(trifluoromethyl)coumarin
7-amino-4-trifluoromethylcoumarin
7-amino-4-(trifluoromethyl)chromen-2-one
Coumarin 151,laser grade
EINECS 258-599-1
2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)-
描述 7-Amino-4-(trifluoromethyl)coumarin (AFC, Coumarin 151) 是荧光标记物,可用来灵敏的检测蛋白酶。它的激发和发射波长分别为400和500 nm。
相关类别
体外研究 7-氨基-4-(三氟甲基)香豆素的氨基酸和肽衍生物用于监测肽酶活性。使用荧光化合物N-乙酰基-asp-glu-val-asp-7-氨基-4-(三氟甲基)香豆素(Ac-DEVD-AFC)测量胱天蛋白酶活化。该底物快速进入细胞,在那里通过特异性半胱天冬酶在天冬氨酸残基上有效裂解,产生荧光化合物7-氨基-4-(三氟甲基)香豆素(AFC)。细胞破碎后,在HPLC上分离释放的7-氨基-4-(三氟甲基)香豆素,并通过荧光检测。细胞内7-氨基-4-(三氟甲基)香豆素的出现被pancaspase抑制剂苄氧基羰基-val-ala-asp-fluoromethylcone阻断,从而确定细胞内caspase是切割的原因[1]。合成γ-谷氨酰基-7-氨基-4-(三氟甲基)香豆素,并用作γ-戊二酰基转肽酶的荧光测定法的底物。反应产物7-氨基-4-(三氟甲基)香豆素在中性pH值下发荧光,激发和发射波长分别为400和490nm,浓度与荧光线性相关,范围为10-300pmol/3mL反应混合物[2]。
参考文献

[1]. Tao Z, et al. Caspase activation by anticancer drugs: the caspase storm. Mol Pharm. 2007 Jul-Aug;4(4):583-95.

[2]. White IN, et al. A continuous fluorometric assay for gamma-glutamyltranspeptidase. Anal Biochem. 1996 Jan 1;233(1):71-5.
密度 1.5±0.1 g/cm3
沸点 314.6±42.0 °C at 760 mmHg
熔点 221-222 °C(lit.)
分子式 C10H6F3NO2
分子量 229.155
闪点 144.1±27.9 °C
精确质量 229.035065
PSA 56.23000
LogP 1.64
蒸汽压 0.0±0.7 mmHg at 25°C
折射率 1.562
储存条件

保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

稳定性

如果遵照规格使用和储存则不会分解，未有已知危险反应

计算化学

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:6

4.可旋转化学键数量:0

5.互变异构体数量:5

6.拓扑分子极性表面积52.3

7.重原子数量:16

8.表面电荷:0

9.复杂度:337

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1
更多

1. 性状：粉末

2. 密度（g/mL,20ºC）：未确定

3. 相对蒸汽密度（g/mL,空气=1）： 未确定

4. 熔点（ºC）：221-223

5. 沸点（ºC）：未确定

6. 沸点（ºC，5mm hg）：未确定

7. 折射率：未确定

8. 闪点（°C）：未确定

9. 比旋光度（ºC）：未确定

10. 自燃点或引燃温度（ºC）： 未确定

11. 蒸气压（kPa,20ºC）：未确定

12. 饱和蒸气压（kPa,60ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19. 溶解性：未确定

Name: Coumarin 151 Laser Grade 99% (UV-Vis) Material Safety Data Sheet
Synonym: 2H-1-Benzopyran-2-One,7-Amino-4-(Trifluoromethyl)
CAS: 53518-15-3
Section 1 - Chemical Product MSDS Name:Coumarin 151 Laser Grade 99% (UV-Vis) Material Safety Data Sheet
Synonym:2H-1-Benzopyran-2-One,7-Amino-4-(Trifluoromethyl)
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
53518-15-3 2H-1-Benzopyran-2-One,7-Amino-4-(Trifl 99 258-599-1
Hazard Symbols: XN
Risk Phrases: 20/21/22 36/37/38
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 53518-15-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: yellow
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 221 - 222 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H6F3NO2
Molecular Weight: 229.16
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas, organic fluorides.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 53518-15-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2H-1-Benzopyran-2-One,7-Amino-4-(Trifluoromethyl) - Not listed by ACGIH, IARC, or NTP.
Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III
Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 53518-15-3: No information available.
Canada
CAS# 53518-15-3 is listed on Canada's NDSL List.
CAS# 53518-15-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 53518-15-3 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

生态学数据:

对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。

危害码 (欧洲) Xn:Harmful;
风险声明 (欧洲) R20/21/22;R36/37/38
安全声明 (欧洲) S26-S36-S37/39
WGK德国 3
海关编码 2932209090
海关编码 2932209090
中文概述 2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

【53518-15-3】化源网提供CAS号/CAS登录号53518-15-3，CAS No.:53518-15-3的msds、结构式、性质、英文名、生产厂家、作用/用途、分子式/化学式、密度、沸点、熔点等。CAS号查询53518-15-3上化源网，专业又轻松。
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