34148-01-1

• 常用中文名：环氯茚酸
• 常用英文名：Clidanac
• CAS号：34148-01-1
• 分子式：C₁₆H₁₉ClO₂
• 分子量：278.77400
• 相关类别： 原料药 解热镇痛药 镇痛药
• 发布时间：2018-03-25 08:00:00
• 更新时间：2024-01-09 11:31:42
• Clidanac是一种有效的抗炎剂。Clidanac可以解偶联氧化磷酸化,可用于类风湿关节炎的研究[1]。

名称

• 中文名: 环氯茚酸
• 英文名: Clidanac
• 中文别名: 6-氯-5-环己基-1-茚羧酸; 氯茚满酸
• 英文别名: (+-)-6-Chlor-5-cyclohexyl-1-indancarbonsaeure; 1H-Indene-1-carboxylic acid,6-chloro-5-cyclohexyl-2,3-dihydro-(9ci); 6-chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid; 6-Chloro-5-cyclohexyl-1-indancarboxylic acid; Britai; 6-chloro-5-cyclohexylindan-1-carboxylic acid; Indanal; (+-)-6-Chlor-5-cyclohexylindan-1-carbonsaeure

物化性质

• 密度: 1.244g/cm3
• 沸点: 424.4ºC at 760mmHg
• 分子式: C₁₆H₁₉ClO₂
• 分子量: 278.77400
• 闪点: 210.5ºC
• 精确质量: 278.10700
• PSA: 37.30000
• LogP: 4.50210
• 折射率: 1.587

生物活性

• 描述: Clidanac是一种有效的抗炎剂。Clidanac可以解偶联氧化磷酸化,可用于类风湿关节炎的研究[1]。
• 相关类别:
  研究领域 >> 感染
• 体外研究: Clidanac可以解偶联氧化磷酸化,并且两种对映异构体的解偶联效力没有差异[1]。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NK4503000 CHEMICAL NAME : 1-Indancarboxylic acid, 6-chloro-5-cyclohexyl- CAS REGISTRY NUMBER : 34148-01-1 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C16-H19-Cl-O2 MOLECULAR WEIGHT : 278.80 WISWESSER LINE NOTATION : L56T&J BVQ HG G- AL6TJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,1297,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 62700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 88400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 825 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 860 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 212 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982

安全

• 海关编码: 2916399090

合成路线

38240-91-4 ~% 34148-01-1

文献：Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372

34177-35-0 ~% 34148-01-1

文献：Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

27634-89-5 ~% 34148-01-1

文献：Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

38913-05-2 ~% 34148-01-1

文献：Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

31861-70-8 ~% 34148-01-1

文献：Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536

31962-03-5 ~% 34148-01-1

文献：Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536

52487-42-0 ~% 34148-01-1

文献：Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372

上下游产品

上游产品  6
38240-91-4 34177-35-0 27634-89-5 38913-05-2
31861-70-8 52487-42-0
下游产品  0

海关

海关编码	2916399090
中文概述	2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%