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89391-50-4

89391-50-4结构式
89391-50-4结构式
  • 常用中文名:咪瑞司他
  • 常用英文名:IMIRESTAT
  • CAS号:89391-50-4
  • 分子式:C15H8F2N2O2
  • 分子量:286.23300
  • 相关类别: 信号通路 代谢酶/蛋白酶 醛糖还原酶
  • 发布时间:2018-07-08 19:13:40
  • 更新时间:2024-01-04 18:33:40
  • Imirestat (AL 1576) 是一种 aldose reductase 抑制剂,可用于治疗糖尿病。

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中文名 咪瑞司他
英文名 2,7-difluorospiro[fluorene-9,5'-imidazolidine]-2',4'-dione
英文别名 Imirestatum [INN-Latin]
Alcon 1576
2,7-Difluorospiro(fluorene-9,4'-imidazolidine)-2',5'-dione
2,7-di-fluoro-spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione
Imirestat
spiro-[2,7-difluorofluoren-9,4'-imidazolidine]-2',5'-dione
Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione,2,7-difluoro
[14C]-Imirestat
Spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione
HOE 843
描述 Imirestat (AL 1576) 是一种 aldose reductase 抑制剂,可用于治疗糖尿病。
相关类别
体内研究 Imirestat(1 mg/kg)可改善神经传导速度,但不会影响对缺氧传导阻滞的抵抗或胰岛素刺激的对人体敏感的ATP酶活性的缺陷[1]。
参考文献

[1]. Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401.

密度 1.58g/cm3
分子式 C15H8F2N2O2
分子量 286.23300
精确质量 286.05500
PSA 58.20000
LogP 2.68580
折射率 1.692
储存条件 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WH1307300
CHEMICAL NAME :
Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-
CAS REGISTRY NUMBER :
89391-50-4
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H8-F2-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg/14D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
700 mg/kg/14D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997

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89391-50-4结构式

89391-50-4

文献:Alcon Laboratories, Inc. Patent: US4436745 A1, 1984 ; Title/Abstract Full Text Show Details Alcon Laboratories, Inc. Patent: US4540700 A1, 1985 ;
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