3412-76-8

• 常用中文名：N,N-二苄基乙二胺二盐酸盐
• 常用英文名：1,2-Ethanediamine,N1,N2-bis(phenylmethyl)-, hydrochloride (1:2)
• CAS号：3412-76-8
• 分子式：C₁₆H₂₂Cl₂N₂
• 分子量：313.26500
• 发布时间：2018-06-15 18:01:55
• 更新时间：2024-01-05 18:50:12

• 长效青霉素的中间体.

名称

• 中文名: N,N-二苄基乙二胺二盐酸盐
• 英文名: n,n'-dibenzylethylenediamine dihydrochloride
• 中文别名: N,N'-二苄基乙二胺二盐酸盐
• 英文别名: N,N'-dibenzylethylenediammonium dichloride; f212; 1,2-Bis(benzylamino)ethanedihydrochloride; N,N'-dibenzyl-ethylenediamine,dihydrochloride; N,N'-Dibenzyl-aethylendiamin,Hydrochlorid; dbeddihydrochloride; 1,2-Bis(benzylamino)ethane2HCl; nn-Dibenzylethylenediamine2HCl; N,N'-Dibenzyl-aethylendiamin,Dihydrochlorid; RARECHEM AQ A1 0039; EINECS 222-300-2

物化性质

• 沸点: 373.8ºC at 760mmHg
• 分子式: C₁₆H₂₂Cl₂N₂
• 分子量: 313.26500
• 闪点: 220.5ºC
• 精确质量: 312.11600
• PSA: 24.06000
• LogP: 4.95180
• 储存条件:

  内衬塑料袋，外用纸箱包装。

• 稳定性:

  无臭无味。化学性质稳定。298℃分解。水中溶解度23.9mg/mL。

• 分子结构:

  1、 摩尔折射率：76.74

  2、 摩尔体积（cm³/mol）：233.5

  3、 等张比容（90.2K）：591.5

  4、 表面张力（dyne/cm）：41.1

  5、 极化率（10-24cm3）：30.42

• 更多:

  1.性状：白色鳞片状晶体

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KV3450000 CHEMICAL NAME : Ethylenediamine, N,N'-dibenzyl-, dihydrochloride CAS REGISTRY NUMBER : 3412-76-8 LAST UPDATED : 199506 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C16-H20-N2.2Cl-H MOLECULAR WEIGHT : 313.30 WISWESSER LINE NOTATION : R1M2M1R &GH &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 555 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,633,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 104 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 1,504,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,628,1959

安全

• 风险声明 (欧洲): R22;R36/37/38
• 海关编码: 2921590090

合成路线

100-52-7 107-15-3 ~66% 4597-81-3 3412-76-8

文献：Pallavicini, Marco; Valoti, Ermanno; Piccolo, Oreste Journal of Chemical Research, Synopses, 1995 , # 11 p. 472 - 473

74677-20-6 ~90% 3412-76-8 78617-23-9

文献：Lloyd, Douglas; Vincent, Colin A.; Walton, David J. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1981 , p. 801 - 805

71201-44-0 ~% 3412-76-8

文献：Lloyd, Douglas; Vincent, Colin A.; Walton, David J. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1981 , p. 801 - 805

100-52-7 ~% 3412-76-8

文献：Velasquez, Angela Maria Arenas; Francisco, Acacio Ivo; Kohatsu, Andrea Akiko Nakaima; Silva, Flavia Alves De Jesus; Rodrigues, Danilo Fernando; Teixeira, Rafaela Gomes Da Silva; Chiari, Bruna Galdorfini; De Almeida, Maria Gabriela Jose; Isaac, Vera Lucia Borges; Vargas, Maria D.; Cicarelli, Regina Maria Barretto Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1707 - 1710

104-71-2 ~% 3412-76-8

文献：Velasquez, Angela Maria Arenas; Francisco, Acacio Ivo; Kohatsu, Andrea Akiko Nakaima; Silva, Flavia Alves De Jesus; Rodrigues, Danilo Fernando; Teixeira, Rafaela Gomes Da Silva; Chiari, Bruna Galdorfini; De Almeida, Maria Gabriela Jose; Isaac, Vera Lucia Borges; Vargas, Maria D.; Cicarelli, Regina Maria Barretto Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1707 - 1710

上下游产品

上游产品  4
100-52-7 107-15-3 71201-44-0 104-71-2
下游产品  1
69239-61-8

制备

氯化苄和乙二胺在碱性条件下缩合成N，N'-二苄基乙二胺，再以稀乙醇为溶剂。滴加盐酸酸化成盐，静置冷却结晶，离心脱水，干燥而得成品。

海关

海关编码	2921590090
中文概述	2921590090. 其他芳香多胺及衍生物及它们的盐. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%