9002-96-4

• 常用中文名：托可索仑
• 常用英文名：Tocofersolan
• CAS号：9002-96-4
• 分子式：C₃₅H₅₈O₆
• 分子量：574.83
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-03-13 08:00:00
• 更新时间：2024-01-03 11:05:20
• Tocofersolan是一种合成的维生素E, 用作维生素E补充剂, 治疗个体维E缺乏症, 也用在化妆品和药品中作为抗氧化剂。

名称

• 中文名: 维生素E聚乙二醇琥珀酸酯
• 英文名: Vitamin E-TPGS
• 中文别名: 托可索仑
• 英文别名: Poly(oxy-1,2-ethanediyl), α-[2-[2-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutoxy]ethoxy]ethyl]-ω-hydroxy-; Tocofersolan; α-(2-{2-[(4-Oxo-4-{[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl]oxy}butanoyl)oxy]ethoxy}ethyl)-ω-hydroxypoly(oxyethylene); Vitamin E TPGS

物化性质

• 密度: 1.01g/cm3
• 沸点: 662.7ºC at 760mmHg
• 熔点: 34-38ºC
• 分子式: C₃₅H₅₈O₆
• 分子量: 574.83
• 闪点: 195.4ºC
• PSA: 100.52000
• LogP: 8.38890
• 外观性状: 透明无色固体
• 折射率: 1.496
• 储存条件: 2~8°C

生物活性

• 描述: Tocofersolan是一种合成的水溶性维生素E。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Rehim WM, et al. Antioxidant capacity in Fasciola hepatica patients before and after treatment with triclabendazole alone or in combination with ascorbic acid (vitamin C) and tocofersolan (vitamin E). Arzneimittelforschung. 2003;53(3):214-20.

MSDS

Name: d-alpha-Tocopheryl polyethylene glycol 1000 succinate Material Safety Data Sheet Synonym: CAS: 9002-96-4 Section 1 - Chemical Product MSDS Name:d-alpha-Tocopheryl polyethylene glycol 1000 succinate Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 9002-96-4 D-alpha-tocoph unlisted Hazard Symbols: Not available. Risk Phrases: Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Target Organs: None. Potential Health Effects The toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Keep container closed when not in use. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels. Exposure Limits +--------------------+-------------------+-------------------+-----------------+ | Chemical Name | ACGIH | NIOSH |OSHA - Final PELs| |--------------------|-------------------|-------------------|-----------------| | D-alpha-tocoph |none listed |none listed |none listed | +--------------------+-------------------+-------------------+-----------------+ OSHA Vacated PELs: D-alpha-tocoph: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Not available. Appearance: clear, colorless Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 36 deg C Autoignition Temperature: Not available. Flash Point: Not available. NFPA Rating: Not published. Explosion Limits, Lower: Not available. Upper: Not available. Decomposition Temperature: Solubility: Specific Gravity/Density: Molecular Formula: Molecular Weight: Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, strong oxidants. Incompatibilities with Other Materials: Not available. Hazardous Decomposition Products: Irritating and toxic fumes and gases. Hazardous Polymerization: Not available. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 9002-96-4: TR1581200 LD50/LC50: Not available. Carcinogenicity: D-alpha-tocoph - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Chemical waste generators must determine whether a discarded chemical is classif as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Part Additionally, waste generators must consult state and local hazardous waste regu ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14 - TRANSPORT INFORMATION CDG/CPL Not classified as hazardous for supply. Canadian TDG No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 9002-96-4: No information available. United Kingdom Occupational Exposure Limits Canada None of the chemicals in this product are listed on the DSL/NDSL list. WHMIS: Not available. CAS# 9002-96-4 is not listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 9002-96-4 is not listed on the TSCA inventory. It is for research and development use only. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. SARA Section 302 (RQ) None of the chemicals in this material have an RQ. Section 302 (TPQ) None of the chemicals in this product have a TPQ. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TR1581200 CHEMICAL NAME : Poly(oxy-1,2-ethanediyl), alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)- 1,4-dioxobutyl)-omega -hydroxy-, (2R-(2R*(4R*,8R*)))- CAS REGISTRY NUMBER : 9002-96-4 LAST UPDATED : 199409 DATA ITEMS CITED : 1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >7 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 25,273,1977

安全

• 危害码 (欧洲): O