62625-22-3

• 常用中文名：锌试剂钠盐
• 常用英文名：Zincon monosodium salt
• CAS号：62625-22-3
• 分子式：C₂₀H₁₅N₄O₆S_.Na
• 分子量：462.41
• 相关类别： 研究领域 其他
• 发布时间：2018-04-10 08:00:00
• 更新时间：2024-01-02 06:24:50
• Zincon sodium 是一种检测水溶液中锌、铜离子的优良比色试剂。Zincon sodium 可用于金属蛋白中锌、铜、钴离子的测定。

名称

• 中文名: 锌试剂
• 英文名: zincon
• 中文别名: 锌钠混合试剂; [邻[2-(2-羟基-5-磺基苯偶氮)亚苄基]肼基苯甲酸; 邻[2-(2-羟基-5-磺基苯偶氮)亚苄基]肼基苯甲酸; 邻[2-（2-羟基-5-磺基苯偶氮）亚苄基]肼基苯甲酸单钠盐; 5-(2-羧基苯基)-1-(2-羟基-5-磺基苯基)-3-苯基甲NFDB9; 锌单钠盐; 2-羧基-2''-羟基-5''-磺基苯鐕基苯
• 英文别名: EINECS 263-651-1; ZINCON MONOSODIUM SALT; 2-[N'''-(2-hydroxy-5-sulfo-phenyl)-3-phenyl-formazano]-benzoic acid,sodium-salt; Benzoic acid, 2-[(2E)-2-[[(E)-2-(2-hydroxy-5-sulfophenyl)diazenyl]phenylmethylene]hydrazinyl]-; 2-[(2E)-2-{[(E)-(2-Hydroxy-5-sulfophenyl)diazenyl](phenyl)methylene}hydrazino]benzoic acid; MFCD00064385; 2-[N'''-(2-Hydroxy-5-sulfo-phenyl)-3-phenyl-formazano]-benzoesaeure,Natrium-Salz; 5-(o-Carboxyphenyl)-1-(2-hydroxy-5-sulfophenyl)-3-phenyl forMazan; ZINCON SODIUM; 2-CARBOXY-2'-HYDROXY-5'-SULFOFORMAZYLBENZENE SODIUM SALT; ZINCON extrapure AR

物化性质

• 密度: 1.5±0.1 g/cm3
• 熔点: 250-260 °C (dec.)
• 分子式: C₂₀H₁₅N₄O₆S_.Na
• 分子量: 462.41
• PSA: 169.39000
• LogP: 3.16
• 外观性状: 暗微红的紫色粉末
• 折射率: 1.682
• 储存条件:

  存放在密封容器内，并放在阴凉，干燥处。储存的地方必须远离氧化剂。

• 稳定性:

  远离氧化物。

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：3

  3、 氢键受体数量：10

  4、 可旋转化学键数量：7

  5、 拓扑分子极性表面积（TPSA）：160

  6、 重原子数量：32

  7、 表面电荷：0

  8、 复杂度：932

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：2

  14、 共价键单元数量：2

• 更多:

  1. 性状：红棕色粉末。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：250-260

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：微溶于水和乙醇，易溶于碱性溶液。在碱性溶液中显红色。

生物活性

• 描述: Zincon sodium 是一种检测水溶液中锌、铜离子的优良比色试剂。Zincon sodium 可用于金属蛋白中锌、铜、钴离子的测定。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Säbel CE, et al. A spectrophotometric method for the determination of zinc, copper, and cobalt ions in metalloproteins using Zincon. Anal Biochem. 2010 Feb 15;397(2):218-26.

MSDS

Name: Zincon monosodium salt Material Safety Data Sheet Synonym: Benzoic acid, 2-[[[(2-hydroxy-5-sulfophenyl)azo]phenylmethylene]hydrazino]-, monosodium salt; o-[2-[alpha(2-Hydroxy-5-sulfophenylazo)benzylidene]hydrazino]benzoic acid sodium salt CAS: 62625-22-3 Section 1 - Chemical Product MSDS Name:Zincon monosodium salt Material Safety Data Sheet Synonym:Benzoic acid, 2-[[[(2-hydroxy-5-sulfophenyl)azo]phenylmethylene]hydrazino]-, monosodium salt; o-[2-[alpha(2-Hydroxy-5-sulfophenylazo)benzylidene]hydrazino]benzoic acid sodium salt Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 62625-22-3 Zincon, monosodium salt 100 263-651-1 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Use with adequate ventilation. Avoid breathing dust. Storage: Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 62625-22-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: dark red Odor: none reported pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C20H15N4NaO6S Molecular Weight: 462.41 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 62625-22-3 unlisted. LD50/LC50: Not available. Carcinogenicity: Zincon, monosodium salt - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 62625-22-3: No information available. Canada CAS# 62625-22-3 is listed on Canada's DSL List. CAS# 62625-22-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 62625-22-3 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 对水稍微有危害的，不要让未稀释或者大量产品接触地下水，水道或者污水系统。若无政府许可，勿将材料排入周围环境。

安全

• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

制备

1.用少量水将邻氨基苯甲酸搅拌成糊状，慢慢加入浓盐酸，冷至0℃后加入亚硝酸钠进行重氮化反应，然后，在10℃下加入用水调成的20%的亚硫酸钠糊状物、乙酸和锌粉，搅拌下保温2h，当溶液透明后，滤去不溶物，滤液冷却后，加入浓盐酸，静置冷却结晶所得邻羧基苯肼晶体制成饱和水溶液过滤后的滤液在搅拌下加入1 ∶ 1的苯甲-乙醇溶液至黄色糊状物析出，继续搅拌10～20min，过滤后得苯甲醛缩-2-羧基苯腙，备用。上述过程反应式为：

向邻羟基苯胺-5-磺酸中加入冰水和盐酸，使之冷到5℃以下，搅拌下慢慢加入亚硝酸钠溶液进行重氮反应，以碘化钾-淀粉试纸控制终点。重氮化结束后，将备用的苯腙与5%的氢氧化钠混合而成的溶液在搅拌下慢慢加入，并补加氢氧化钠溶液至全溶，控制温度不超过10℃，静置2h后过滤，滤液中加乙酸至酸性，析出的结晶用乙醇重结晶后得纯品。