93236-42-1

• 常用中文名：肉苁蓉苷A
• 常用英文名：Cistanoside A
• CAS号：93236-42-1
• 分子式：C₃₆H₄₈O₂₀
• 分子量：800.754
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-07-21 08:18:12
• 更新时间：2024-01-02 22:22:23
• Cistanoside A 是肉苁蓉中的苯丙素类化合物,可减少 NO 的聚集,但对诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性都没有作用。具有抗炎活性。

名称

• 中文名: 肉苁蓉苷 A
• 英文名: [(2R,3R,4R,5R,6R)-5-hydroxy-6-[2-(4-hydroxy-3-methoxyphenyl)ethoxy]-2-[[(2R,3R,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• 中文别名: 肉苁蓉苷A
• 英文别名: 2-(4-Hydroxy-3-methoxyphenyl)ethyl 6-deoxy-α-L-mannopyranosyl-(1->3)-[α-L-idopyranosyl-(1->6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-β-D-glucopyranoside; cistanoside A; 2-(4-Hydroxy-3-methoxyphenyl)ethyl 6-deoxy-α-L-mannopyranosyl-(1->3)-[α-L-idopyranosyl-(1->6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-β-D-glucopyranoside; β-D-Glucopyranoside, 2-(4-hydroxy-3-methoxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1->3)-O-[α-L-idopyranosyl-(1->6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]-; I07-0327; 2-(4-Hydroxy-3-methoxyphenyl)ethyl 6-deoxy-α-L-mannopyranosyl-(1->3)-β-D-glucopyranosyl-(1->6)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-β-D-glucopyranoside; β-D-Glucopyranoside, 2-(4-hydroxy-3-methoxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->6)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]-

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 1058.1±65.0 °C at 760 mmHg
• 分子式: C₃₆H₄₈O₂₀
• 分子量: 800.754
• 闪点: 324.2±27.8 °C
• 精确质量: 800.273865
• PSA: 313.44000
• LogP: 2.46
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.676
• 储存条件: 室温

生物活性

• 描述: Cistanoside A 是肉苁蓉中的苯丙素类化合物,可减少 NO 的聚集,但对诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性都没有作用。具有抗炎活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Xiong Q, et al. Inhibition of nitric oxide by phenylethanoids in activated macrophages. Eur J Pharmacol. 2000 Jul 14;400(1):137-44.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LZ5901500 CHEMICAL NAME : Glucopyranoside, 2-(4-hydroxy-3-methoxyphenyl)ethyl O-6-deoxy-alpha-L-mannopyranosyl- (1-3)-O-(beta-D-glucopyranosyl-(1-6))-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)-beta-D- CAS REGISTRY NUMBER : 93236-42-1 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C36-H48-O20 MOLECULAR WEIGHT : 800.84 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 140 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 105,1131,1985