6859-01-4

• 常用中文名：异钩藤碱
• 常用英文名：Isorhyncophylline
• CAS号：6859-01-4
• 分子式：C₂₂H₂₈N₂O₄
• 分子量：384.47
• 相关类别： 天然产物 生物碱
• 发布时间：2018-09-06 06:22:22
• 更新时间：2024-01-02 20:17:51
• 异钩藤碱 (Isorhynchophylline) 是从钩藤中分离得到的生物碱类化合物,能够降血压、舒张血管、保护神经免于局部缺血造成损伤。

名称

• 中文名: 异钩藤碱
• 英文名: isorhynchophylline
• 英文别名: 7-Isorhynchophylline; 5-Methoxyindole-3-carboxylic Acid Hydrate; 7-Isorhyncophylline; 5-Methoxyindole-3-Carboxylic Acid; (16E,20α)-17-Methoxy-2-oxocorynox-16-en-16-carboxylic acid; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, (αE,3S,6'R,7'S,8'aS)-; Isorhyncophylline; 5-methoxyindole-2-carboxylic acid; 1H-Indole-3-carboxylic acid, 5-methoxy-; 5-Methoxy-1H-indole-3-carboxylic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 447.6±25.0 °C at 760 mmHg
• 熔点: 114ºC
• 分子式: C₂₂H₂₈N₂O₄
• 分子量: 384.47
• 闪点: 224.5±23.2 °C
• PSA: 78.87000
• LogP: 1.90
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.677
• 储存条件: 室温

生物活性

• 描述: 异钩藤碱 (Isorhynchophylline) 是从钩藤中分离得到的生物碱类化合物,能够降血压、舒张血管、保护神经免于局部缺血造成损伤。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 其他
• 参考文献:

  [1]. Yan-Fang Xian, et al. Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice. Neurochemistry International Volume 76, October 2014, Pages 42–49

  [2]. Guo H, et al. Isorhynchophylline protects against pulmonary arterial hypertension and suppresses PASMCs proliferation. Biochem Biophys Res Commun. 2014 Jul 18;450(1):729-34.

  [3]. LI Qiang, et al. Inhibitory effect of isorhynchophylline on cardiomyocyte hypertrophy induced by angiotensinⅡ. West China JOurnal of Pharmaceutical Sciences, 2013-05

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GN1605000 CHEMICAL NAME : Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20-alpha)- CAS REGISTRY NUMBER : 6859-01-4 LAST UPDATED : 198909 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C22-H28-N2-O4 MOLECULAR WEIGHT : 384.52 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 217 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

安全

• 安全声明 (欧洲): 24/25