中文名 | 聚丙烯酸 |
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英文名 | Carbomer |
中文别名 |
卡波姆
羧基乙烯共聚物 卡波姆940 |
英文别名 |
2-(Chloromethyl)-2-[(2-naphthyloxy)methyl]-1,3-propanediol
poly(acrylic acid) 1,3-Propanediol, 2-(chloromethyl)-2-[(2-naphthalenyloxy)methyl]- Carbomer 940 |
描述 | 卡波姆共聚物可用作赋形剂,如生物粘合剂、乳化剂、释放改性剂、悬浮剂、片剂粘合剂、增粘剂等。药用赋形剂或药用助剂是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。 |
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相关类别 | |
参考文献 |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 502.0±45.0 °C at 760 mmHg |
熔点 | 12.5ºC |
分子式 | C3H4O2 |
分子量 | 280.747 |
闪点 | 257.4±28.7 °C |
精确质量 | 280.086609 |
PSA | 37.30000 |
LogP | 4.01 |
外观性状 | 白色松散粉末 |
蒸汽压 | 0.0±1.4 mmHg at 25°C |
折射率 | 1.619 |
储存条件 | 室温,干燥,密封 |
Section 1. Chemical Product and Company Identification Carbomer 1342, 1622 Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym
Chemical Name Chemical Family Carbomer 1342, 1622 Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature 520°C (968°F) Flash PointsNot available. Flammable LimitsNot available. These products are carbon oxides (CO, CO2), phosphates. Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onAs with most organic solids, fire is possible at elevated temperatures. Fire HazardsMaterial in powder form, capable of creating a dust explosion. Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust Hazardsexplosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Carbomer 1342, 1622 Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection Safety glasses. Lab coat. Dust respirator is ot normally required. Use a dust respirator if ventilation is not adequate and if handling of material (particularly in large quantities) creates visible dust clouds. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid.OdorAcetic acid. (Slight.) TasteNot available. Molecular WeightNot available. White. Color 2.5 - 3.0 [Acidic.] pH (1% soln/water) Boiling PointNot available. Not available. Melting Point Critical TemperatureNot available. Specific Gravity1.4 (Water = 1) Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. SolubilityEasily soluble in cold water, hot water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, incompatible materials, dust generation. Incompatibility with variousReactive with alkalis. substances CorrosivityNon-corrosive in presence of glass. Carbomer 1342, 1622 Heat may be generated if polymer comes in contact with strong basic materials such as ammonia, sodium Special Remarks on Reactivityhydroxide, postassium hydroxide or stronly basic amines. Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryDermal contact. Inhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 2000 mg/kg [Guinea pig]. Acute dermal toxicity (LD50): 3000 mg/kg [Rabbit]. Chronic Effects on Humans CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. May cause damage to the following organs: upper respiratory tract, skin, eyes. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: Dust may cause irritation by mechanical action, not by chemical effect. Inhalation: Inhalation of dust may cause irritation by mechanical action, not by chemical effect. Symptoms may include coughing, mucous production, and shortness of breath Ingestion: Low hazard. Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may cause dermatits. Medical Conditions Aggravated by Exposure: Pre-existing respiratory diseases; pre-existing skin problems. I Section 12. Ecological Information Ecotoxicity in water (LC50): 580 - 2000 mg/l 96 hours [Fish (Bluegill, Sunfish)]. 168 - 280 mg/l 96 hours Ecotoxicity [Daphnia (daphnia)]. BOD5 and CODNot available. Possibly hazardous short term degradation products are not likely. However, long term degradation products may Products of Biodegradation arise. The product itself and its products of degradation are not toxic. Toxicity of the Products of Biodegradation Not available. Special Remarks on the Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Carbomer 1342, 1622 Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Not applicable. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Carbomer 1342, 1622 Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsCanada: Listed on Canadian Domestic Substance List (DSL). Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC)This product is not classified according Not applicable. to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Carbomer 1342, 1622 Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. SECTION 16 - ADDITIONAL INFORMATION N/A |
危害码 (欧洲) | C: Corrosive; |
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风险声明 (欧洲) | 45-46 |
安全声明 (欧洲) | 53-45 |
危险品运输编码 | UN 3265 8/PG 3 |
海关编码 | 3906909090 |
海关编码 | 3906909090 |
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