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470-42-8

470-42-8结构式

常用中文名：海蟾蜍毒素
常用英文名：Marinobufogenin
CAS号：470-42-8
分子式：C₂₄H₃₂O₅
分子量：400.508
相关类别：研究领域其他
发布时间：2018-06-11 21:59:23
更新时间：2024-01-04 16:58:44
Marinobufogenin 是 Na+/K+ ATPase 的高效抑制剂,最初从哺乳动物血浆中鉴定得到。

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中文名	海蟾蜍毒素
英文名	Marinobufagenin
英文别名	(3β,5β,15β)-3,5-Dihydroxy-14,15-epoxybufa-20,22-dienolide 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5-dihydroxy- 5beta-Bufa-20,22-dienolide,14,15beta-epoxy-3beta,5-dihydroxy Bufa-20,22-dienolide,14,15-epoxy-3,5-dihydroxy-,(3beta,5beta,15beta) Marinobufagenin Marinobufogenin Marinobufagin Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β)- MARCINOBUFAGIN 5-hydroxyl-resibufogenin

描述	Marinobufogenin 是 Na+/K+ ATPase 的高效抑制剂,最初从哺乳动物血浆中鉴定得到。
相关类别	研究领域 >> 其他
靶点	IC50: Na+/K+ ATPase[1]
参考文献	[1]. Daniel N, et al. Bufodienolides in pig plasma and urine.

密度	1.3±0.1 g/cm3
沸点	589.0±50.0 °C at 760 mmHg
分子式	C₂₄H₃₂O₅
分子量	400.508
闪点	203.0±23.6 °C
精确质量	400.224976
PSA	83.20000
LogP	1.25
蒸汽压	0.0±3.7 mmHg at 25°C
折射率	1.621
储存条件	2-8°C，避光，干燥，密封

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2963000

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,5-dihydroxy-14,15-beta-epoxy-

CAS REGISTRY NUMBER :: 470-42-8

LAST UPDATED :: 199009

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C24-H32-O5

MOLECULAR WEIGHT :: 400.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2730 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 152 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1520 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 556 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963

危害码 (欧洲)	Xi

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