370881-96-2

• 常用中文名：(1s,6r)-3-boc-3,8-二氮杂双环[4.2.0]辛烷
• 常用英文名：2-Methyl-2-Propanyl 3,8-Diazabicyclo[4.2.0]Octane-3-Carboxylate
• CAS号：370881-96-2
• 分子式：C₁₁H₂₀N₂O₂
• 分子量：212.289
• 发布时间：2019-01-01 15:20:18
• 更新时间：2025-08-26 06:56:37

名称

• 中文名: (1S,6R)-3-BOC-3,8-二氮杂双环[4.2.0]辛烷
• 英文名: 3-Boc-3,8-diazabicyclo[4.2.0]octane
• 英文别名: 2-Methyl-2-propanyl (1S,6R)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate; 3,8-Diazabicyclo[4.2.0]octane-3-carboxylic acid, 1,1-dimethylethyl ester, (1S,6R)-; 2-Methyl-2-propanyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate; tert-butyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate; cis-3-Boc-3,8-diazabicyclo[4,2,0]octane; 3,8-Diazabicyclo[4.2.0]octane-3-carboxylic acid, 1,1-dimethylethyl ester

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 295.4±13.0 °C at 760 mmHg
• 分子式: C₁₁H₂₀N₂O₂
• 分子量: 212.289
• 闪点: 132.5±19.8 °C
• 精确质量: 212.152481
• PSA: 41.57000
• LogP: 0.84
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.494
• 储存条件: 室温，干燥

合成路线

1293940-99-4 ~75% 370881-96-2

文献：JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T. Patent: WO2011/50202 A1, 2011 ; Location in patent: Page/Page column 64-65 ; WO 2011/050202 A1

923956-64-3 ~88% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

923956-59-6 ~% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

388108-67-6 ~% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

848591-74-2 ~% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

24424-99-5 ~% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

52763-21-0 ~% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

71233-25-5 ~% 370881-96-2

文献：Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853

上下游产品

上游产品  5
1293940-99-4 848591-74-2 24424-99-5 52763-21-0
71233-25-5
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