毒理学数据:
急性数据:人经口TDLo:480 mg/kg;
大鼠经口LD50:484 mg/kg;
大鼠吸入LC50:200 ppm/4H;
大鼠腹腔LD50:65 mg/kg;
小鼠经口LD50:470 mg/kg;
小鼠吸入LC50:170 ppm/4H;
其他多剂量毒性数据
大鼠经口TDLo:2033 mg/kg;
大鼠腹腔TDLo:273 mg/kg;
致肿瘤数据
小鼠实验TDLo:282 mg/kg;
生态学数据:
该物质对环境有危害,应特别注意对大气的污染
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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EL9450000
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CHEMICAL NAME :
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2-Butanone, peroxide
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CAS REGISTRY NUMBER :
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1338-23-4
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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31
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MOLECULAR FORMULA :
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C8-H16-O4
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MOLECULAR WEIGHT :
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176.24
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WISWESSER LINE NOTATION :
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1V2OO2V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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480 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
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REFERENCE :
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NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC) Volume(issue)/page/year: Jan/Feb,1969
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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484 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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200 ppm/4H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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65 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness Behavioral - ataxia
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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470 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 165,201,1957
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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170 ppm/4H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2033 mg/kg/7W-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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273 mg/kg/7W-I
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TOXIC EFFECTS :
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Related to Chronic Data - death
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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282 mg/kg
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REFERENCE :
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RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued. Volume(issue)/page/year: 3,193,1963 *** REVIEWS *** ACGIH TLV-CL 1.5 mg/m3 (0.2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-BELGIUM:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-DENMARK:STEL 1 mg/m3 JAN 1993 OEL-FINLAND:STEL 0.2 ppm (1.5 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-SWEDEN:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.2 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ETHYL KETONE PEROXIDE-air:CL 0.2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80105 No. of Facilities: 2226 (estimated) No. of Industries: 29 No. of Occupations: 31 No. of Employees: 20053 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80105 No. of Facilities: 1879 (estimated) No. of Industries: 23 No. of Occupations: 31 No. of Employees: 25827 (estimated) No. of Female Employees: 6514 (estimated)
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