6536-18-1

• 常用中文名：吗拉宗
• 常用英文名：Morazone
• CAS号：6536-18-1
• 分子式：C₂₃H₂₇N₃O₂
• 分子量：377.47900
• 发布时间：2018-06-15 12:57:53
• 更新时间：2023-01-16 10:35:24
• Morazone is a nonsteroidal anti-inflammatory drug which is used as an analgesic. It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.

名称

• 中文名: 吗拉宗
• 英文名: 1,5-dimethyl-4-[(3-methyl-2-phenylmorpholin-4-yl)methyl]-2-phenylpyrazol-3-one
• 英文别名: 1,5-dimethyl-4-(3-methyl-2-phenyl-morpholinomethyl)-2-phenyl-1,2-dihydro-pyrazol-3-one; 1,5-Dimethyl-4-(3-methyl-2-phenyl-morpholinomethyl)-2-phenyl-1,2-dihydro-pyrazol-3-on; Morazonum [INN-Latin]; R 445; EINECS 229-447-1; Morazone; 1,5-dimethyl-4-(3-methyl-2-phenyl-morpholin-4-ylmethyl)-2-phenyl-1,2-dihydro-pyrazol-3-one; Tarugan; Novartrina; Morazona [INN-Spanish]; Orsimon

物化性质

• 密度: 1.153g/cm3
• 沸点: 503.9ºC at 760 mmHg
• 分子式: C₂₃H₂₇N₃O₂
• 分子量: 377.47900
• 闪点: 258.5ºC
• 精确质量: 377.21000
• PSA: 39.40000
• LogP: 3.38430
• 折射率: 1.587

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ9200000 CHEMICAL NAME : 3-Pyrazolin-5-one, 2,3-dimethyl-4-(3-methyl-2-phenylmorpholino)methyl-1- phenyl- CAS REGISTRY NUMBER : 6536-18-1 BEILSTEIN REFERENCE NO. : 0347917 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C23-H27-N3-O2 MOLECULAR WEIGHT : 377.53 WISWESSER LINE NOTATION : T6N DOTJ B1 CR& A1- DT5NNVJ A1 BR E1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 5,346,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 5,346,1965

合成路线

50-00-0 134-49-6 60-80-0 ~% 6536-18-1

文献：Hengen et al. Arzneimittel Forschung, 1958 , vol. 8, p. 421

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