50-39-5

• 常用中文名：氟氯西林
• 常用英文名：protheobromine
• CAS号：50-39-5
• 分子式：C₁₀H₁₄N₄O₃
• 分子量：238.24300
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-08-28 20:08:07
• 更新时间：2025-08-25 17:15:51
• Protheobromine是强心剂和支气管扩张剂。

名称

• 中文名: 氟氯西林
• 英文名: 1-(2-hydroxypropyl)-3,7-dimethylpurine-2,6-dione
• 中文别名: 丙可可碱
• 英文别名: 1-(2-Hydroxy-propyl)-3,7-dimethyl-3,7-dihydro-purin-2,6-dion; Bonicor; Theocor; 1-<2-Hydroxy-propyl>-3,7-dimethyl-xanthin; Pro-Cor; Corodil; Cordabromin; Pantobromino; Protheobromin; Vascopil; Cordaleromin; Protheobromine; 1-(2-hydroxy-propyl)-3,7-dimethyl-3,7-dihydro-purine-2,6-dione

物化性质

• 密度: 1.46g/cm3
• 沸点: 493.1ºC at 760mmHg
• 分子式: C₁₀H₁₄N₄O₃
• 分子量: 238.24300
• 闪点: 252ºC
• 精确质量: 238.10700
• PSA: 82.05000
• 折射率: 1.664

生物活性

• 描述: Protheobromine是强心剂和支气管扩张剂。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. D M Aviado, Pharmacology of pentoxifylline, a hemorheologic agent for the treatment of intermittent claudication. Angiology. 1984 Jul;35(7):407-17.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XH2387000 CHEMICAL NAME : Theobromine, 1-(2-hydroxypropyl)- CAS REGISTRY NUMBER : 50-39-5 BEILSTEIN REFERENCE NO. : 0263332 LAST UPDATED : 199706 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C10-H14-N4-O3 MOLECULAR WEIGHT : 238.28 WISWESSER LINE NOTATION : T56 BN DN FNVNVJ B F H1YQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 780 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 6,457,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 6,601,1956

安全

• 海关编码: 2933990090

合成路线

10244-22-1 ~% 50-39-5

文献：Cavallaro, Rosaria A.; Filocamo, Luigi; Galuppi, Annamaria; Galione, Antony; Brufani, Mario; Genazzani, Armando A. Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2527 - 2534

83-67-0 ~% 50-39-5

文献：Cavallaro, Rosaria A.; Filocamo, Luigi; Galuppi, Annamaria; Galione, Antony; Brufani, Mario; Genazzani, Armando A. Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2527 - 2534

83-67-0 75-56-9 ~% 50-39-5

文献：Roth Archiv der Pharmazie (Weinheim, Germany), 1959 , vol. 292, p. 234,236,237 Full Text Show Details Eckstein; Gorczyca Dissertationes Pharmaceuticae, 1962 , vol. 14, p. 393,-399 Chem.Abstr., 1963 , vol. 59, # 13978

2530-99-6 ~% 50-39-5

文献：Eckstein; Gorczyca Dissertationes Pharmaceuticae, 1962 , vol. 14, p. 393,-399 Chem.Abstr., 1963 , vol. 59, # 13978

108-32-7 83-67-0 ~% 50-39-5

文献：Fabbrini; Cencioni Farmaco, Edizione Scientifica, 1962 , vol. 17, p. 660,665

上下游产品

上游产品  5
10244-22-1 83-67-0 75-56-9 2530-99-6
108-32-7
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%