20004-62-0

• 常用中文名：抗霉素
• 常用英文名：Resistomycin
• CAS号：20004-62-0
• 分子式：C₂₂H₁₆O₆
• 分子量：376.35900
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2016-04-23 05:58:56
• 更新时间：2024-01-05 12:18:26
• 抵抗素是一种五环聚酮类抗生素,具有抗癌活性并诱导细胞凋亡[1][2][3][4]。

名称

• 中文名: 抗霉素
• 英文名: resistomycin
• 英文别名: 3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-2H-benzo[cd]pyrene-2,6(1H)-dione; A 3733A; Itamycin; 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H-benzo[cd]pyrene-2,6-dione; 2H-Benzo(cd)pyrene-2,6(1H)-dione,3,5,7,10-tetrahydroxy-1,1,9-trimethyl; Geliomycin; Antibiotic A 3733a; 3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-1H-benzo[cd]pyren-2,6-dion; Croceomycin

物化性质

• 分子式: C₂₂H₁₆O₆
• 分子量: 376.35900
• 精确质量: 376.09500
• PSA: 115.06000
• LogP: 3.65590
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 抵抗素是一种五环聚酮类抗生素,具有抗癌活性并诱导细胞凋亡[1][2][3][4]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 抵抗素通过抑制E3连接酶Pellino-1和诱导蜗牛/蛞蝓降解来减轻三重阴性乳腺癌的进展[1]。如表面等离子体共振所示,抵抗霉素对GST-Pellino-1(KD=2.58μM)具有高度亲和力[1]。抵抗素处理降低TNBC细胞中蜗牛和蛞蝓的表达[1]。抵抗素通过激活p38 MAPK通路在体内外诱导人肝癌细胞凋亡和周期阻滞[3]。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ6350000 CHEMICAL NAME : 2H-Benzo(cd)pyrene-2,6(1H)-dione, 3,5,7,10-tetrahydroxy-1,1,9-trimethyl- CAS REGISTRY NUMBER : 20004-62-0 BEILSTEIN REFERENCE NO. : 2187224 LAST UPDATED : 199707 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H16-O6 MOLECULAR WEIGHT : 376.38 WISWESSER LINE NOTATION : L C6666 B6 3ABC S GV IV RHJ EQ KQ M1 OQ R1 R1 SQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,354,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,351,1980 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20750 ug/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,539,1983

安全

• 海关编码: 2914400090

合成路线

22852-03-5 ~87% 20004-62-0

文献：Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

96328-31-3 ~% 20004-62-0

文献：Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

96328-34-6 ~% 20004-62-0

文献：Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

96328-32-4 ~% 20004-62-0

文献：Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

海关

海关编码	2914400090
中文概述	2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%