Resistomycin

Modify Date: 2025-08-27 08:45:04

Resistomycin structure	Common Name	Resistomycin
	CAS Number	20004-62-0	Molecular Weight	376.35900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Resistomycin

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].

Name	resistomycin
Synonym	More Synonyms

Description	Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation[1]. Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1]. Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1]. Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[3].

Molecular Formula	C₂₂H₁₆O₆
Molecular Weight	376.35900
Exact Mass	376.09500
PSA	115.06000
LogP	3.65590

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ6350000

CHEMICAL NAME :: 2H-Benzo(cd)pyrene-2,6(1H)-dione, 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-

CAS REGISTRY NUMBER :: 20004-62-0

BEILSTEIN REFERENCE NO. :: 2187224

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H16-O6

MOLECULAR WEIGHT :: 376.38

WISWESSER LINE NOTATION :: L C6666 B6 3ABC S GV IV RHJ EQ KQ M1 OQ R1 R1 SQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,354,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,351,1980 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20750 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,539,1983

HS Code	2914400090

N/A

CAS#:22852-03-5

~87%

Resistomycin

CAS#:20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

N/A

CAS#:96328-31-3

Resistomycin

CAS#:20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

11,11a-dihydro-...

CAS#:96328-34-6

Resistomycin

CAS#:20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

3,5,7,10-tetram...

CAS#:96328-32-4

Resistomycin

CAS#:20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-2H-benzo[cd]pyrene-2,6(1H)-dione

A 3733A

Itamycin

3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H-benzo[cd]pyrene-2,6-dione

2H-Benzo(cd)pyrene-2,6(1H)-dione,3,5,7,10-tetrahydroxy-1,1,9-trimethyl

Geliomycin

Antibiotic A 3733a

3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-1H-benzo[cd]pyren-2,6-dion

Croceomycin

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Resistomycin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Resistomycin
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: RESISTOMYCIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Resistomycin

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.