7060-74-4

• 常用中文名：竹桃霉素
• 常用英文名：Matromycin (phosphate)
• CAS号：7060-74-4
• 分子式：C₃₅H₆₄NO₁₆P
• 分子量：785.854
• 相关类别： 原料药 抗生素类药物 大环内酯类药
• 发布时间：2018-04-17 08:00:00
• 更新时间：2024-01-11 09:11:47

名称

• 中文名: 竹桃霉素
• 英文名: oleandomycin phosphate
• 英文别名: Oleandomycin,Dihydrogenphosphat; 1,9-dioxaspiro[2.13]hexadecane-4,10-dione, 12-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-, phosphate (1:1) (salt); Einecs 230-351-7; (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranoside phosphate (1:1); oleandomycin standard solution; oleandomycin,phosphate(1:1)(salt); Matromycin (phosphate); Oleandomycin,phosphate (1:1); (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-Hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3 -O-methyl-α-L-arabino-hexopyranoside phosphate (1:1); Unii-8681H0C27p; Oleandomycin dihydrate phosphate salt; matromycin; 1,9-Dioxaspiro[2.13]hexadecane-4,10-dione, 12-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyra nosyl]oxy]-, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-, phosphate (1:1) (salt); oleandomycin,dihydrogenphosphate

物化性质

• 熔点: 145-147℃
• 分子式: C₃₅H₆₄NO₁₆P
• 分子量: 785.854
• 精确质量: 785.396301
• PSA: 253.55000
• LogP: 0.97990
• 储存条件:

  一、贮存

  0-6°储存。

• 更多:

  一、物性数据

  性状：不可用

  密度（g/mL,25/4℃）：不可用

  相对蒸汽密度（g/mL,空气=1）：不可用

  熔点（ºC）：不可用

  沸点（ºC,常压）：不可用

  沸点（ºC,5.2kPa）：不可用

  折射率：不可用

  闪点（ºC）：不可用

  比旋光度（º）：不可用

  自燃点或引燃温度（ºC）：不可用

  蒸气压（kPa,25ºC）：不可用

  饱和蒸气压（kPa,60ºC）：不可用

  燃烧热（KJ/mol）：不可用

  临界温度（ºC）：不可用

  临界压力（KPa）：不可用

  油水（辛醇/水）分配系数的对数值：不可用

  爆炸上限（%,V/V）：不可用

  爆炸下限（%,V/V）：不可用

  溶解性：不可用

毒性和生态

毒理学数据: 二、毒理学数据： 急性毒性：不可用。 生态学数据: 三、生态学数据： 1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : RJ9800000 CAS REGISTRY NUMBER : 7060-74-4 LAST UPDATED : 199403 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C35-H61-N-O12.H3-O4-P MOLECULAR WEIGHT : 785.97 WISWESSER LINE NOTATION : T-14-VO GVXTJ C1 D1 EQ F1 J1 L1 N1 H-& BT3OX CHJ& KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 480 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,419,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 19 mg/m3/4H/10W-I TOXIC EFFECTS : Liver - liver function tests impaired Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(11),83,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.4 mg/m3;Skin JAN 1993

安全

• 危害码 (欧洲): T+
• 风险声明 (欧洲): 28
• 安全声明 (欧洲): S22;S24/25
• 危险品运输编码: UN2811 6.1/PG 2
• RTECS号: RJ9800000