435273-75-9

• 常用中文名：茚达特罗中间体
• 常用英文名：(R)-8-(Benzyloxy)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-2(1H)-one
• CAS号：435273-75-9
• 分子式：C₃₁H₃₄N₂O₃
• 分子量：482.61300
• 发布时间：2017-04-13 15:14:07
• 更新时间：2024-01-06 16:33:30

名称

• 中文名: 茚达特罗中间体
• 英文名: 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-phenylmethoxy-1H-quinolin-2-one
• 英文别名: 8-benzyloxy-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-1H-quinolin-2-one; 8-phenylmethoxy-5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-1H-quinolin-2-one; (R)-8-(benzyloxy)-5-(2-(5,6-diethyl-2,3-dihydro-1H-inden-2-ylamino)-1-hydroxyethyl)quinolin-2(1H)-one; 8-benzyloxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one; Indacaterol Impurity 7

物化性质

• 沸点: 734.1±60.0 °C
• 分子式: C₃₁H₃₄N₂O₃
• 分子量: 482.61300
• 精确质量: 482.25700
• PSA: 74.35000
• LogP: 5.41320
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi

合成路线

173140-90-4 312753-70-1 ~28% 435273-75-9

文献：Baur, Francois; Beattie, David; Beer, David; Bentley, David; Bradley, Michelle; Bruce, Ian; Charlton, Steven J.; Cuenoud, Bernard; Ernst, Roland; Fairhurst, Robin A.; Faller, Bernard; Farr, David; Keller, Thomas; Fozard, John R.; Fullerton, Joe; Garman, Sheila; Hatto, Julia; Hayden, Claire; He, Handan; Howes, Colin; Janus, Diana; Jiang, Zhengjin; Lewis, Christine; Loeuillet-Ritzler, Frederique; Moser, Heinz; Reilly, John; Steward, Alan; Sykes, David; Tedaldi, Lauren; Trifilieff, Alexandre; Tweed, Morris; Watson, Simon; Wissler, Elke; Wyss, Daniel Journal of Medicinal Chemistry, 2010 , vol. 53, # 9 p. 3675 - 3684

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