78249-43-1

• 常用中文名：Acetamide, N-(6,7,8,10-tetrahydro-4,11-dimethoxy-10-oxoheptaleno(1,2-e)-1,3-benzodioxol-8-yl)-, (S)-
• 常用英文名：Acetamide, N-(6,7,8,10-tetrahydro-4,11-dimethoxy-10-oxoheptaleno(1,2-e)-1,3-benzodioxol-8-yl)-, (S)-
• CAS号：78249-43-1
• 分子式：C₂₁H₂₁NO₆
• 分子量：383.39500
• 发布时间：2017-07-30 10:27:17
• 更新时间：2024-01-09 11:27:53

名称

• 英文名: 1,2-(Methylenedioxy)-1,2-demethylcolchicine
• 英文别名: cornigerine

物化性质

• 密度: 1.35g/cm3
• 沸点: 743.5ºC at 760 mmHg
• 分子式: C₂₁H₂₁NO₆
• 分子量: 383.39500
• 闪点: 403.5ºC
• 精确质量: 383.13700
• PSA: 83.09000
• LogP: 2.97400
• 折射率: 1.623

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC8587100 CHEMICAL NAME : Acetamide, N-(6,7,8,10-tetrahydro-4,11-dimethoxy-10-oxoheptaleno (1,2-e)-1,3- benzodioxol-8-yl)-, (S)- CAS REGISTRY NUMBER : 78249-43-1 LAST UPDATED : 198912 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C21-H21-N-O6 MOLECULAR WEIGHT : 383.43 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 64 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

合成路线

74-97-5 78231-83-1 ~73% 78249-43-1

文献：Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

74-97-5 78231-84-2 ~% 78249-43-1

文献：Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

64-86-8 ~% 78249-43-1

文献：Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

78231-83-1 ~% 78249-43-1

文献：Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688