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IC50: 4.1 µM (Keap1-Nrf2); Kd: 3.7 µM[1]
[1]. Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.