796041-65-1

• 常用中文名：JAK3抑制剂VII,AD412
• 常用英文名：JAK3 Inhibitor VII, AD412
• CAS号：796041-65-1
• 分子式：C₂₃H₂₀ClN₃O
• 分子量：389.88
• 发布时间：2022-03-26 11:18:24
• 更新时间：2024-01-03 11:29:31
• JAK3抑制剂VII，AD412是一种细胞可渗透的吲哚-3-丙酰胺免疫抑制剂，与JAK2的活性（分别为29％和0）相比，选择性抑制JAK3激酶活性（分别在90和30μM时分别抑制81％和36％）。分别在90和30μM时产生％），并降低IL-2刺激的CTL-L2细胞中Akt，STAT5a / b和Erk1 / 2的JAK1和JAK3依赖性磷酸化，但不降低INF中JAK1 / 2依赖性STAT1磷酸化-γ刺激的U266培养物。据报道，JAK3抑制剂VII，AD412在体外抑制ConA刺激的鼠脾细胞和PHA刺激 JAK3 Inhibitor VII, AD412 is a cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit JAK3 kinase activity (by 81% and 36% at 90 and 30 μM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 μM, respectively) and reduce JAK1 and JAK3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. JAK3 Inhibitor VII, AD412 is reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC|50|= 17 and 25 μM, respectively)|in vitro|.

名称

• 中文名: JAK3抑制剂VII,AD412
• 英文名: JAK3 Inhibitor VII, AD412
• 英文别名: MFCD28138099; N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide; 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(pyridin-4-yl)propanamide; 1H-Indole-3-propanamide, 1-[(4-chlorophenyl)methyl]-N-4-pyridinyl-; 3-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-N-(4-pyridinyl)propanamide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 669.0±55.0 °C at 760 mmHg
• 分子式: C₂₃H₂₀ClN₃O
• 分子量: 389.88
• 闪点: 358.4±31.5 °C
• 精确质量: 389.129486
• LogP: 5.41
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.642
• 储存条件: 2-8°C储存