100012-18-8

• 常用中文名：MnTMPyP五氯化物
• 常用英文名：Mntmpyp Pentachloride
• CAS号：100012-18-8
• 分子式：C₄₄H₃₆MnN₈Cl₅
• 分子量：909
• 发布时间：2022-03-27 18:33:39
• 更新时间：2025-08-25 18:13:00
• MnTMPyP五氯化物是一种细胞可渗透的锰卟啉，可作为超氧化物歧化酶（SOD）模拟物和过氧亚硝酸盐清除剂。即使在过量的EDTA存在下，也显示出催化O | 2- |歧化的能力。MnTMPyP五氯化物还显示出对星形胶质细胞中H | 2 | O | 2 |介导的损伤的保护作用。 MnTMPyP pentachloride is a cell-permeable, manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. It has displayed the ability to catalyze the dismutation of O|2-|, even in the presence of excess EDTA. MnTMPyP pentachloride also displays a protective effect against H|2|O|2|-mediated injury in astroglial cells.

名称

• 中文名: MnTMPyP五氯化物
• 英文名: MnTMPyP pentachloride
• 英文别名: CM-4307; 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-; Sorafenib; MFCD06411450; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; Manganese (III) tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methyl-2-pyridinecarboxamide; 9ZOQ3TZI87

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 523.3±50.0 °C at 760 mmHg
• 分子式: C₄₄H₃₆MnN₈Cl₅
• 分子量: 909
• 闪点: 270.3±30.1 °C
• 精确质量: 464.086304
• LogP: 5.16
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.626
• 储存条件: -20°C储存
• 水溶解性: Soluble in water, 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50 mg/ml), and PBS, pH 7.2 (4 mg/ml).

安全

• 危害码 (欧洲): N