154652-83-2

• 常用中文名：Tezampanel
• 常用英文名：Tezampanel
• CAS号：154652-83-2
• 分子式：C₁₃H₂₁N₅O₂
• 分子量：279.33800
• 发布时间：2017-07-12 07:21:00
• 更新时间：2025-08-28 18:18:00
• Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor.

名称

• 英文名: tezampanel
• 英文别名: (-)(3S,4aR,6R,8aR)-6-(2-(1(2)H-tetrazole-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid monohydrate; (3S,4aR,6R,8aR)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydro-isoquinoline-3-carboxylic acid; (3S,4aR,6R,8aR)-6-[2-(1H-tetrazol-5-yl)-ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid

物化性质

• 密度: 1.252g/cm3
• 沸点: 527.3ºC at 760mmHg
• 分子式: C₁₃H₂₁N₅O₂
• 分子量: 279.33800
• 闪点: 272.7ºC
• 精确质量: 279.17000
• PSA: 103.79000
• LogP: 0.94010

合成路线

157006-68-3 ~% 154652-83-2

文献：Phosphorus, Sulfur and Silicon and Related Elements, , vol. 109, # 1-4 p. 309 - 312

157006-69-4 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

162491-31-8 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

157006-72-9 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

156893-77-5 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

157006-71-8 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

159406-70-9 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

160225-05-8 ~% 154652-83-2

文献：Journal of Organic Chemistry, , vol. 59, # 25 p. 7862 - 7869

67-56-1 2537-48-6 157006-69-4 ~% 154652-83-2

文献：Phosphorus, Sulfur and Silicon and Related Elements, , vol. 109, # 1-4 p. 309 - 312

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