352-91-0

• 常用中文名：1-溴-3-氟丙烷
• 常用英文名：1-Bromo-3-fluoropropane
• CAS号：352-91-0
• 分子式：C₃H₆BrF
• 分子量：140.982
• 相关类别： 有机原料 有机氟化合物 氟丙烷系列
• 发布时间：2018-08-22 08:39:14
• 更新时间：2024-01-06 20:24:48

名称

• 中文名: 1-溴-3-氟丙烷
• 英文名: 1-bromo-3-fluoropropane
• 中文别名: 1-氟-3-溴丙烷
• 英文别名: 3-fluoro-1-bromopropane; 1-Fluoro-3-bromopropane; 3-Fluorobromopropane; Propane, 1-bromo-3-fluoro-; Propane,1-bromo-3-fluoro; 1-bromo-3-fluoro-propane; 1-Bromo-3-fluoropropane; 3-Fluoropropyl bromide; 3-Bromo-1-fluoropropane; 1-bromo-3-flioropropane

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 101.2±8.0 °C at 760 mmHg
• 分子式: C₃H₆BrF
• 分子量: 140.982
• 闪点: 16.4±13.3 °C
• 精确质量: 139.963684
• LogP: 1.69
• 外观性状: 透明无色液体
• 蒸汽压: 40.9±0.2 mmHg at 25°C
• 折射率: 1.408
• 储存条件: 室温
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.7

  2.氢键供体数量:0

  3.氢键受体数量:1

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积:0

  7.重原子数量:5

  8.表面电荷:0

  9.复杂度:16.4

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

MSDS

Name: 1-Bromo-3-fluoropropane Material Safety Data Sheet Synonym: None CAS: 352-91-0 Section 1 - Chemical Product MSDS Name:1-Bromo-3-fluoropropane Material Safety Data Sheet Synonym:None Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 352-91-0 1-Bromo-3-fluoropropane 100 221-525-3 Hazard Symbols: XI Risk Phrases: 10 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Flammable. Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Inhalation: Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Vapors may cause dizziness or suffocation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Wash hands before eating. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels. Exposure Limits CAS# 352-91-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: colorless Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 99 - 101 deg C @ 760.00mm Hg Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: 23 deg C ( 73.40 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: 1.583 Molecular Formula: C3H6BrF Molecular Weight: 140.98 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Mechanical shock, incompatible materials, ignition sources, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents, strong reducing agents, strong bases, strong acids. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride gas, hydrogen bromide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 352-91-0: TX4122500 LD50/LC50: Not available. Carcinogenicity: 1-Bromo-3-fluoropropane - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: FLAMMABLE LIQUID, N.O.S.* Hazard Class: 3 UN Number: 1993 Packing Group: III IMO Shipping Name: FLAMMABLE LIQUID, N.O.S. Hazard Class: 3.3 UN Number: 1993 Packing Group: III RID/ADR Shipping Name: FLAMMABLE LIQUID, N.O.S. Hazard Class: 3 UN Number: 1993 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 10 Flammable. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 9 Keep container in a well-ventilated place. S 16 Keep away from sources of ignition - No smoking. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 33 Take precautionary measures against static discharges. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 352-91-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 352-91-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 352-91-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TX4122500 CHEMICAL NAME : Propane, 1-bromo-3-fluoro- CAS REGISTRY NUMBER : 352-91-0 BEILSTEIN REFERENCE NO. : 1731089 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C3-H6-Br-F HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 174,737,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

安全

• 危害码 (欧洲): F: Flammable;T: Toxic;N: Dangerous for the environment;Xn: Harmful;
• 风险声明 (欧洲): R10
• 安全声明 (欧洲): 23-36/37/39-59-26-36-16
• 危险品运输编码: UN 1993 3
• RTECS号: TX4122500
• 海关编码: 2903799090

合成路线

109-64-8 ~% 352-91-0

文献：Journal of Organic Chemistry, , vol. 14, p. 107

462-43-1 ~% 352-91-0

文献：Journal of Organic Chemistry, , vol. 15, p. 425,427

109-64-8 ~34% 352-91-0 1871-72-3 111483-20-6

文献：Journal of Organic Chemistry USSR (English Translation), , vol. 23, # 2 p. 237 - 242 Zhurnal Organicheskoi Khimii, , vol. 23, # 2 p. 269 - 274

2623-87-2 ~89% 352-91-0

文献：Patrick, Timothy B.; Johri, Kamalesh K.; White, David H.; Bertrand, William S.; Mokhtar, Rodziah; et al. Canadian Journal of Chemistry, 1986 , vol. 64, p. 138 - 141

109-70-6 ~% 352-91-0

文献：Molecular Crystals and Liquid Crystals (1969-1991), , vol. 131, p. 353 - 360

103935-48-4 ~% 352-91-0

文献：Journal of Organic Chemistry, , vol. 52, # 4 p. 658 - 664

109-64-8 ~% 462-39-5 352-91-0

文献：US2721201 , ; Journal of Organic Chemistry, , vol. 15, p. 425,427

109-64-8 ~% 352-91-0 1871-72-3

文献：Journal of Organic Chemistry USSR (English Translation), , vol. 20, p. 1255 - 1263 Zhurnal Organicheskoi Khimii, , vol. 20, # 7 p. 1379 - 1388

107-21-1 109-64-8 ~% 462-39-5 352-91-0 详细

文献：Journal of Organic Chemistry, , vol. 14, p. 107

上下游产品

上游产品  6
109-64-8 462-43-1 2623-87-2 109-70-6
103935-48-4 107-21-1
下游产品  9
462-39-5 462-40-8 63636-89-5 133120-18-0
155797-99-2 648956-81-4 462-74-8 407-83-0
408-00-4

海关

海关编码	2903799090
中文概述	2903799090 其他无环烃卤化衍生物（含二种或三种以上不同卤素）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
Summary	2903799090 halogenated derivatives of acyclic hydrocarbons containing two or more different halogens。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%