67292-68-6

• 常用中文名：2-(5-甲氧基-2-甲基-1H-吲哚-3-基)-N,N-二甲基乙胺
• 常用英文名：2-(5-methoxy-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine
• CAS号：67292-68-6
• 分子式：C₁₄H₂₀N₂O
• 分子量：232.32100
• 发布时间：2018-12-25 17:25:30
• 更新时间：2024-01-02 18:40:27

名称

• 中文名: 2-(5-甲氧基-2-甲基-1H-吲哚-3-基)-N,N-二甲基乙胺
• 英文名: 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine
• 英文别名: 2-methyl-5-methoxy-N,N-dimethyltryptamine; Methyl-2-methoxy-5-N-dimethyltryptamine; 4365 CT

物化性质

• 密度: 1.079g/cm3
• 沸点: 383.7ºC at 760 mmHg
• 分子式: C₁₄H₂₀N₂O
• 分子量: 232.32100
• 闪点: 185.8ºC
• 精确质量: 232.15800
• PSA: 28.26000
• LogP: 2.58900
• 折射率: 1.589

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NL7400000 CHEMICAL NAME : Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl- CAS REGISTRY NUMBER : 67292-68-6 BEILSTEIN REFERENCE NO. : 0179917 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C14-H20-N2-O HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 74 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BSCFAS Bulletin de la Societe Chimique de France. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1864- Volume(issue)/page/year: (5),1411,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BSCFAS Bulletin de la Societe Chimique de France. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1864- Volume(issue)/page/year: (5),1411,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 48 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BSCFAS Bulletin de la Societe Chimique de France. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1864- Volume(issue)/page/year: (5),1411,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BSCFAS Bulletin de la Societe Chimique de France. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1864- Volume(issue)/page/year: (5),1411,1965

合成路线

79098-38-7 19501-58-7 ~77% 67292-68-6

文献：SUVEN LIFE SCIENCES LIMITED Patent: WO2004/41781 A1, 2004 ; Location in patent: Page 11 ;

28089-03-4 ~79% 67292-68-6

文献：Merck Sharp and Dohme Ltd. Patent: US6187805 B1, 2001 ; US 6187805 B1

50-00-0 28089-03-4 ~79% 67292-68-6

文献：Russell; Baker; Barden; Beer; Bristow; Broughton; Knowles; McAllister; Patel; Castro Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3881 - 3895

100722-77-8 ~% 67292-68-6

文献：Shaw Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320 Journal of the American Chemical Society, 1956 , vol. 78, p. 6419

1076-74-0 ~% 67292-68-6

文献：Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J. Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374

1026388-93-1 ~% 67292-68-6

文献：Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J. Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374

2882-15-7 ~% 67292-68-6

文献：Shaw Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320 Journal of the American Chemical Society, 1956 , vol. 78, p. 6419

189884-58-0 ~% 67292-68-6

文献：Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J. Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374

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