1924207-18-0

• 常用中文名：PF-06463922 acetate
• 常用英文名：PF-06463922 acetate
• CAS号：1924207-18-0
• 分子式：C₂₃H₂₃FN₆O₄
• 分子量：466.465
• 发布时间：2021-01-16 15:20:09
• 更新时间：2023-02-18 01:35:29
• PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).

名称

• 英文名: Lorlatinib acetate
• 英文别名: Lorlatinib acetate; (16R)-19-Amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetraazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10,12,14,18,20-octaene-3-carbonitrile acetate (1:1); (10R).7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H.8,4-(metheno)pyrazolo[4,3.h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile acetate; PF-06463922 acetate; 2H-8,4-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-, acetate (1:1)

物化性质

• 分子式: C₂₃H₂₃FN₆O₄
• 分子量: 466.465
• 精确质量: 466.176483