1781834-99-8

• 常用中文名：ARRY 520 trifluoroacetate
• 常用英文名：ARRY 520 trifluoroacetate
• CAS号：1781834-99-8
• 分子式：C₂₂H₂₃F₅N₄O₄S
• 分子量：534.499
• 发布时间：2021-01-10 19:58:32
• 更新时间：2024-01-07 18:09:06
• Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents.

名称

• 英文名: ARRY-520
• 英文别名: Acetic acid, 2,2,2-trifluoro-, compd. with (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (1:1); (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate (1:1); ARRY-520

物化性质

• 分子式: C₂₂H₂₃F₅N₄O₄S
• 分子量: 534.499
• 精确质量: 534.135986