| 英文名 | SNAP-7941 |
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| 英文别名 |
Methyl (4S)-3-({3-[4-(3-acetamidophenyl)-1-piperidinyl]propyl}carbamoyl)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
SNAP-7941 5-Pyrimidinecarboxylic acid, 1-[[[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]amino]carbonyl]-6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-, methyl ester, (6S)- methyl (4S)-3-[(3-{4-[3-(acetylamino)phenyl]piperidin-1-yl}propyl)carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
| 描述 | SNAP-7941是一种选择性,高亲和力和竞争性MCH1受体(MCH1-R)拮抗剂,Ki为15 nM；抑制中枢给予MCH刺激的食物摄入,减少可口食物的消耗,降低饮食诱导的大鼠体重肥胖；在抑郁/焦虑的动物模型中也产生类似于临床使用的抗抑郁药和抗焦虑药的效果。肥胖停止了 |
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| 参考文献 | References 1. Borowsky B, et al. Nat Med. 2002 Aug;8(8):825-30. 2. Basso AM, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. 3. Millan MJ, et al. Int J Neuropsychopharmacol. 2008 Dec;11(8):1105-22. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR) Obesity |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 分子式 | C33H41F2N5O6 |
| 分子量 | 613.652 |
| 精确质量 | 613.271179 |
| LogP | 2.47 |
| 折射率 | 1.572 |
