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| 中文名 | 甘草酰胺 |
|---|---|
| 英文名 | gambogic amide |
| 英文别名 |
2-Butenamide, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
gambogic amide (2Z)-4-[(1S,2S,8R,17S,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,
 11,15-pentaen-19-yl]-2-methyl-2-butenamide |
| 描述 | 一种有效的选择性高亲和力TrkA受体激动剂,Kd为75 nM；选择性结合TrkA,但不结合TrkB或TrkC,并强烈诱导其酪氨酸磷酸化和下游信号激活,包括Akt和MAPKs；有效抑制细胞周期蛋白A1表达并阻断K562细胞增殖；在小鼠中风的短暂大脑中动脉闭塞模型中减少红藻氨酸触发的神经细胞死亡并减少梗塞体积。 |
|---|---|
| 参考文献 | References 1. Jang SW, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34. 2. Chan CB, et al. Oncogene. 2009 Oct 29;28(43):3825-36. 3. Obianyo O, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8. View Related Products by Target Trk Receptor |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 823.9±65.0 °C at 760 mmHg |
| 分子式 | C38H45NO7 |
| 分子量 | 627.766 |
| 闪点 | 452.1±34.3 °C |
| 精确质量 | 627.319580 |
| LogP | 9.24 |
| 蒸汽压 | 0.0±3.1 mmHg at 25°C |
| 折射率 | 1.627 |