1354712-92-7

• 常用中文名：PF05020182
• 常用英文名：PF05020182
• CAS号：1354712-92-7
• 分子式：C₁₈H₃₀N₄O₄
• 分子量：366.455
• 发布时间：2018-06-24 20:39:14
• 更新时间：2023-10-18 20:25:15
• PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.

名称

• 英文名: PF-05020182
• 英文别名: N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethylbutanamide; N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl-butanamide; Butanamide, N-[4,6-dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl-; PF-05020182

物化性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₁₈H₃₀N₄O₄
• 分子量: 366.455
• 精确质量: 366.226715
• LogP: 4.42
• 折射率: 1.534

安全

• 危险品运输编码: NONH for all modes of transport