1319738-39-0

• 常用中文名：BI1002494
• 常用英文名：BI1002494
• CAS号：1319738-39-0
• 分子式：C₂₃H₂₅N₃O₅
• 分子量：423.462
• 发布时间：2018-07-04 23:14:24
• 更新时间：2025-11-03 13:33:53
• BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin).

名称

• 英文名: (4R)-4-[(1R)-1-{[7-(3,4,5-Trimethoxyphenyl)-1,6-naphthyridin-5-yl]oxy}ethyl]-2-pyrrolidinone
• 英文别名: (4R)-4-[(1R)-1-{[7-(3,4,5-Trimethoxyphenyl)-1,6-naphthyridin-5-yl]oxy}ethyl]-2-pyrrolidinone; 2-Pyrrolidinone, 4-[(1R)-1-[[7-(3,4,5-trimethoxyphenyl)-1,6-naphthyridin-5-yl]oxy]ethyl]-, (4R)-

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 609.6±55.0 °C at 760 mmHg
• 分子式: C₂₃H₂₅N₃O₅
• 分子量: 423.462
• 闪点: 322.5±31.5 °C
• 精确质量: 423.179413
• LogP: 0.95
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.592