1399840-35-7

• 常用中文名：MTDIA
• 常用英文名：MTDIA
• CAS号：1399840-35-7
• 分子式：
• 分子量：
• 发布时间：2018-05-03 15:34:02
• 更新时间：2025-08-20 08:06:34
• MTDIA, also known as MT-DADMe-ImmA, and Methylthio-DADMe-Immucillin A, is a MTAP inhibitor. Human 5'-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. Transition-state (TS) analogues of MTAP are in development as anticancer candidates. TS analogues of MTAP incorporate a cationic nitrogen and a protonated 9-deazaadenine leaving group, which are mimics of the ribocation transition state. MT-ImmA and MT-DADMe-ImmA are two examples of these TS analogues.

名称

• 英文名: MT-DADMe-ImmA
• 英文别名: MTDIA HCl

物化性质

暂时没有任何物化性质资料