83843-39-4

• 常用中文名：GYKI-23107
• 常用英文名：GYKI-23107
• CAS号：83843-39-4
• 分子式：C₁₃H₂₄Cl₂N₂
• 分子量：279.24900
• 发布时间：2016-02-27 17:36:33
• 更新时间：2023-10-21 20:15:55
• GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.

名称

• 英文名: 1-N-(2,6-dimethylphenyl)-2-N,2-N-dimethylpropane-1,2-diamine,dihydrochloride

物化性质

• 沸点: 312.5ºC at 760 mmHg
• 分子式: C₁₃H₂₄Cl₂N₂
• 分子量: 279.24900
• 闪点: 117.5ºC
• 精确质量: 278.13200
• PSA: 15.27000
• LogP: 4.34240

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TX8032260 CHEMICAL NAME : 1,2-Propanediamine, N(sup 2),N(sup 2)-dimethyl-N(sup 1)-2,6-xylyl-, dihydrochloride CAS REGISTRY NUMBER : 83843-39-4 LAST UPDATED : 199712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C13-H22-N2.2Cl-H MOLECULAR WEIGHT : 279.29 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 390 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 114 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987