140405-36-3

• 常用中文名：N'-(4-(二乙基氨基)-2-羟基亚苄基)异烟酰肼
• 常用英文名：RSVA 405
• CAS号：140405-36-3
• 分子式：C₁₇H₂₀N₄O₂
• 分子量：312.36600
• 发布时间：2018-05-14 01:53:58
• 更新时间：2025-11-04 11:15:11
• RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity.

名称

• 中文名: N'-(4-(二乙基氨基)-2-羟基亚苄基)异烟酰肼
• 英文名: N'-[1-(4-diethylamino-2-hydroxyphenyl)methylidene]isonicotinohydrazide
• 英文别名: p-(N,N-diethylamino)salicylaldehyde isonicotinoylhydrazone; N'-[4-(diethylamino)-2-hydroxybenzylidene]isonicotinohydrazide; Hit2Lead 5113025; ST 91

物化性质

• 分子式: C₁₇H₂₀N₄O₂
• 分子量: 312.36600
• 精确质量: 312.15900
• PSA: 77.82000
• LogP: 2.78820
• 储存条件: 2-8°C， 干燥