103577-40-8

• 常用中文名：兰索拉唑硫醚
• 常用英文名：Lansoprazole Sulfide
• CAS号：103577-40-8
• 分子式：C₁₆H₁₄F₃N₃OS
• 分子量：353.362
• 发布时间：2018-08-08 15:55:54
• 更新时间：2026-06-30 18:32:40
• Lansoprazole sulfide is an impurity of Lansoprazole -- a gastric pump inhibitor.

名称

• 中文名: 2-[[[3-甲基-4-(2,2,2三氟乙氧基)-2-吡啶]-甲基]硫基]-1H-苯并咪唑
• 英文名: 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
• 中文别名: 右旋兰索拉唑杂质C; 兰索拉唑相关化合物B; 兰索拉唑中间体; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶]甲基硫基-1H-苯并咪唑; 兰索拉唑杂质C(兰索拉唑硫化物); 兰索拉唑相关物质B; 兰索拉唑杂质C(兰索拉唑相关化合物B); 2-[[[3-甲基-4-(2,2,2三氟乙氧基)-2-吡啶]-甲基]硫基]-1H-苯并咪唑(简称硫化物); 2-[3-甲基-4-(2,2,2; 2-3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶甲基硫基-1H-苯并咪唑; 兰索拉唑杂质C; 兰索拉唑杂质C(兰索拉唑相关化合物B(游离形式),兰索拉唑硫化物); 兰索拉唑缩合物; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-哌啶基]甲基硫基-1H-苯并咪唑; 兰索拉唑硫脒; 2-[-[(3-甲基-4-(2,2,2-三氟乙氧基)- 2-吡啶基)甲基]巯基]苯并咪唑; 兰索拉唑杂质C/杂质B; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶基甲基硫]苯并咪唑; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶]甲基硫基-1H-苯并咪唑X; 2-(((3-甲基-4-(2,2,2-三氟乙氧基)吡啶-2-基)甲基)硫基)-1H-苯并[D]咪唑; 兰索拉唑杂质C 标准品; 兰索拉唑杂质对照品C; 南索拉唑杂质B; 兰索拉唑硫化物; 兰索拉唑硫醚(杂质C); 右兰索拉唑杂质C; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶]甲基硫基-1H-苯并咪; 兰索拉唑杂质3(兰索拉唑杂质C); 2-[-[(3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶基)甲基]巯基]苯并咪唑; 兰索拉唑杂质 3; 兰索拉唑EP杂质C; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-哌啶基]甲基硫代-1H-苯并咪唑; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶]甲基硫基-1H-苯并咪唑(兰索拉唑缩合物); 兰索拉唑硫醚(103-8); 2-[[[3-甲基-4-(2,2,2三氟乙氧基)-2-吡啶]-甲基]硫基]-1H-苯并咪唑 103-8; 兰索硫咪; 2-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶基甲基硫代]-1H-苯并咪唑
• 英文别名: Dexlansoprazole Impurity 9; Imp. B :2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulphonyl]-1Hbenzimidazole(Lansoprazole Sulphone); 2-[[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRID-2YL]METHYLTHIO]BENZIMIDAZOLE; EC -9; LANSOPRAZOLE INTERMEDIATES; Lansoprazole Impurity 3(Lansoprazole Impurity C); 1H-BenziMidazole, 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]; 2-({[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl}sulfanyl)-1H-benzimidazole; 2-(((3-methyl-4-(2,2,2-trifluoroethoxy); T56 BM DNJ CS1- BT6NJ C1 DO1XFFF; 2-(((3-METHYL-4(2,2,2-TRIFLUROETHOXY)-2-PYRIDINYL)METHYL)SULFANYL)-1H-BENZIMIDAZOLE; 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl thio-1H-benziMidazole hydrate; Lansoprazole Sulfide ImpurityQ: What is Lansoprazole Sulfide Impurity Q: What is the CAS Number of Lansoprazole Sulfide Impurity Q: What is the storage condition of Lansoprazole Sulfide Impurity; Lansoprazole Impurity C/Impurity B; 2-[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL ]METHYL THIO-1H-BENZIMIDAZOLE; Lansoprazole Impurity 3; /18; Lansoprazole Impurity B; 2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]Methyl}-1H-1,3-benzodiazole-1-thiol; 2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] t; Dex-Lansoprazole Sulfide/Lansoprazole Impurity C; MFCD00834357; 2-[((3-METHYL-4-(2,2,2 TRIFLUOROETHOXY)2-PYRIDYL)METHYL)THIO)]1H BENZIMIDAZOLE; 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridinyl)thio)-(1H)-binzimidazole; Lansoprazole related substance C; Lansoprazole Related CoMpound B; Lansoprazole-3; 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole; 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole; 2-[[(3-Methyl-4-(2,2,2-Trifluoroethoxy) Pyridinyl) Methyl] Thio]-1H-Benzimidazole; 2-((METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINYL)THIO)-1H-BINZIMIDAZOLE; Lansoprazole Related Compound B (25 mg) (2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]sulfanyl]-1H-benzimidazole); Lansoprazole IMpurity C; 2-[[[3-Methyl-4-(2,2,2-trifluoromethoxy)pyrid-2-yl]methyl]thio]benzimidazole; Lansoprazole Impurity C/ Lansoprazole Related Compound B (Lansoprazole Sulfide); Lansoprazole IMpurity-Sulfide -IMpurity C); lansoprazole sulphide; 2-[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL]METHYL THIO-1H-BENZIMIDAZOLE; 2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole; 2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] thio]-1H-benzimidazole; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]; 2-[[[3-Methyl-4-(2,2,2-Trifluoroethyoxy)-2-Pyridyl]-Methyl]Thio]-1H-Benzimidazole; 2-[3-Methyl-4-(2,2,2-Trifluoroethoxy)Methylthio-1H-Benzimidazole; 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methylthio]-1H-benzoimidazole; 2-[(1H-Benzoimidazole-2-yl)thiomethyl]-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine; lansoprazole Sulfur ether; 2-[3-Methyl-4-(2,2,2; 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfanyl]-1H-benzimidazole; Lansoprazole Impurity C（）; 2-[3-Methyl-4-(2; Lansoprazole Impurity C (Sulphide); 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole; LANSOPRAZOLE SULFIDE; Lansoprazole Impurity C (Lansoprazole Related Compound B); 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylmethylthio]-1H-benzoimidazole; 1-(methylthio)-2-[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]benzimidazole; Lansoprazole sulphide compound; 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridiny]methylthio-1H- benzimidazole; Lansoprazole Related Compound B (2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]sulfan; Lansoprazole impurity 3/Lansoprazole Impurity C/Lansoprazole Sulfide/2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole; Lansoprazole Impurity C (Lansoprazole Sulfide)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 494.9±55.0 °C at 760 mmHg
• 熔点: 149-150ºC
• 分子式: C₁₆H₁₄F₃N₃OS
• 分子量: 353.362
• 闪点: 253.1±31.5 °C
• 精确质量: 353.080963
• PSA: 76.10000
• LogP: 4.46
• 外观性状: 淡黄色固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.616
• 储存条件: -20°C Freezer

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

合成路线

128430-66-0 134469-07-1 ~96% 103577-40-8

文献：Organic Process Research and Development, , vol. 17, # 10 p. 1272 - 1276

1427321-51-4 ~% 103577-40-8

文献：EP1681056 A1, ; Page/Page column 9 ;

103577-61-3 ~% 103577-40-8

文献：Synthetic Communications, , vol. 32, # 8 p. 1211 - 1217

37699-43-7 ~% 103577-40-8

文献：Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858

103577-66-8 134469-07-1 ~% 103577-40-8

文献：Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858

上下游产品

上游产品  6
128430-66-0 134469-07-1 1427321-51-4 103577-61-3
37699-43-7 103577-66-8
下游产品  3
138530-94-6 138530-95-7 103577-45-3

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%