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| 中文名 | 2-(4-氨基苯基)-6-甲基苯并噻唑 |
|---|---|
| 英文名 | 2-(4-Aminophenyl)-6-methylbenzothiazole |
| 中文别名 |
2-对氨基苯基-6-甲基苯并噻唑
脱氢硫代对甲苯胺 4-(6-甲基-2-苯并噻唑)苯胺 |
| 英文别名 |
MFCD00005780
EINECS 202-150-4 4-(6-methyl-1,3-benzothiazol-2-yl)aniline |
| 描述 | 脱氢硫代对甲苯胺(DHPT)是一种用于染料生产的化学中间体。脱氢硫代对甲苯胺在急性和亚慢性条件下表现出吸入毒性[1]。 |
|---|---|
| 相关类别 | |
| 体内研究 | 在平均0.64 mg DHPT/L的条件下,脱氢硫基对甲苯胺(4 h)可诱导小鼠流涎、抓挠和咀嚼运动、流泪、零星束发、快速呼吸和轻微体重减轻[1]。在平均2.41 mg DHPT/L的条件下,脱氢硫基对甲苯胺(4小时)诱导小鼠散发性鼻腔分泌物和嗜睡[1]。与对照组相比,去氢硫代对甲苯胺(5天每天6小时,然后休息两天,然后再暴露5天；0.6 mg DHPT/L)降低了红细胞计数、血红蛋白水平和淋巴细胞的相对数量,排出了大量浓度较低的尿液,在第十次暴露后,产生以肝细胞过度营养和胆管上皮细胞增殖为特征的肝脏变化,并导致胸腺坏死和淋巴细胞耗竭[1]。 |
| 密度 | 1.264 g/cm3 |
|---|---|
| 沸点 | 434°C |
| 熔点 | 191-196°C |
| 分子式 | C14H12N2S |
| 分子量 | 240.32300 |
| 闪点 | 217.3ºC |
| 精确质量 | 240.07200 |
| PSA | 67.15000 |
| LogP | 4.43510 |
| 外观性状 | 淡黄褐色的或淡橙色粉末,溶液有一种紫罗兰色-蓝色荧光 |
| 折射率 | 1.709 |
| 储存条件 | 室温，干燥 |
| 水溶解性 | <0.1 g/100 mL at 20 ºC |
| 分子结构 | 1、 摩尔折射率：74.22 2、 摩尔体积（cm3/mol）：190.0 3、 等张比容（90.2K）：525.2 4、 表面张力（dyne/cm）：58.2 5、 极化率（10-24cm3）：29.42 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:3 4.可旋转化学键数量:1 5.互变异构体数量:3 6.拓扑分子极性表面积67.2 7.重原子数量:17 8.表面电荷:0 9.复杂度:263 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
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Material Safety Data Sheet
Section1. Identification of the substance Product Name: 4-(6-Methyl-2-benzothiazolyl)benzeneamine Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:4-(6-Methyl-2-benzothiazolyl)benzeneamine CAS number:92-36-4 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C14H12N2S Molecular weight:240.3 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
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CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xi: Irritant; |
| 风险声明 (欧洲) | R36/37/38 |
| 安全声明 (欧洲) | S26;S36 |
| 危险品运输编码 | NONH for all modes of transport |
| RTECS号 | DL2820000 |
| 海关编码 | 2934999090 |
| 海关编码 | 2934999090 |
|---|---|
| 中文概述 | 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |