63-56-9

• 常用中文名：盐酸嘧啶二胺
• 常用英文名：thonzylamine hydrochloride
• CAS号：63-56-9
• 分子式：C₁₆H₂₃ClN₄O
• 分子量：322.833
• 相关类别： 医药中间体 杂环化合物 嘧啶类化合物 胺类
• 发布时间：2018-06-21 16:22:25
• 更新时间：2024-01-02 11:50:14

名称

• 中文名: 盐酸嘧啶二胺
• 英文名: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine,hydrochloride
• 英文别名: Novohetramin; Thonzylaminium chloride; N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2-pyrimidyl)ethylenediamine Hydrochloride; Anahist; N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyrimidinyl-1,2-ethanediamineMonohydrochloride; EINECS 200-561-3; Thonzylamine HCl; 1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N-2-pyrimidinyl-, hydrochloride (1:1); UNII-6K9YKD48Y4; THONZYLAMINE HYDROCHLORIDE; N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(2-pyrimidinyl)-1,2-ethanediamine hydrochloride (1:1); N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine hydrochloride; N-(4-methoxybenzyl)-N',N'-dimethyl-N-(pyrimidin-2-yl)ethane-1,2-diamine hydrochloride (1:1); Resistab; Neohetramine hydrochloride; 2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyrimidine hydrochloride

物化性质

• 密度: 1.2562 (rough estimate)
• 沸点: bp2.2 185-187°
• 熔点: 173 - 176ºC
• 分子式: C₁₆H₂₃ClN₄O
• 分子量: 322.833
• 闪点: 220.3ºC
• 精确质量: 322.156036
• PSA: 41.49000
• LogP: 2.85540
• 外观性状: 白色结晶粉末
• 折射率: 1.5800 (estimate)
• 稳定性: Stable. Incompatible with strong oxidizing agents.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV8750000 CHEMICAL NAME : Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, hydrochloride CAS REGISTRY NUMBER : 63-56-9 LAST UPDATED : 198812 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C16-H22-N4-O.Cl-H MOLECULAR WEIGHT : 322.88 WISWESSER LINE NOTATION : T6N CNJ BN1R DO1&2N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,419,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 157 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,83S,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 493 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 38200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 20/21/22
• 安全声明 (欧洲): 36