106-99-0

106-99-0结构式

常用中文名：丁二烯
常用英文名：butadiene
CAS号：106-99-0
分子式：C₄H₆
分子量：54.090
相关类别：有机原料烃类化合物及其衍生物无环烃
发布时间：2018-02-06 08:00:00
更新时间：2024-01-02 08:46:04
【用途一】
用作合成橡胶、合成树脂、合成纤维、增塑剂和乳胶漆等的原料
【用途二】
丁二烯是生产合成橡胶（丁苯橡胶、顺丁橡胶、丁腈橡胶、氯丁橡胶）的主要原料。随着苯乙烯塑料的发展，利用苯乙烯与丁二烯共聚，生产各种用途广泛的树脂（如ABS树脂、SBS树脂、BS树脂、MBS树脂），使丁二烯在树脂生产中逐渐占有重要地位。此外，丁二烯尚用于生产乙叉降冰片烯（乙丙橡胶第三单体）、1,4-丁二醇（工程塑料）、己二腈（尼龙66单体）、环丁砜、蒽醌、四氢呋喃等等。因而也是重要的基础化工原料。丁二烯在精细化学品生产中也有很多用处。以丁二烯为原料制取的精细化学品。主要有以下几个方面。（1）与缺电子嗜双烯化合物发生狄尔斯-阿尔德反应，制得蒽醌，其衍生物是重要染料中间体、杀菌剂和杀虫剂。（2）与顺丁烯二酸酐（简称顺酐）反应，进而缩合，制得四氢苯酐，可作聚酯树酯、环氧树脂的固化剂和增塑剂。四氢苯酐再经硝酸氧化，可得丁烷四羧酸，是制造水溶性漆的原料。同样四氢苯酐加氢制得六氢苯二甲酸酐，可用作为环氧树脂的固化剂。（3）与二氧化硫作用，生成环丁烯砜，然后配制成水溶液在骨架镍催化剂存在下加氢，制得环丁砜，是芳烃萃取用的选择性溶剂。环丁砜和二异丙醇胺的混合物可用脱二氧化碳气体用。（4）丁二烯的线型调聚反应在工业上很有用处。线型二聚后得到八碳直链烯烃，再经醛化、加氢即得壬醇，在合成香料、表面活性剂、润滑油添加剂方面都有重要用途。用钴络合物作催化剂，其二聚、三聚、四聚体，都是合成高级醇和大环麝香的原料。
【用途三】
丁二烯是生产合成橡胶（丁苯橡胶、顺丁橡胶、丁腈橡胶、氯丁橡胶）的主要原料。

中文名	1,3-丁二烯
英文名	buta-1,3-diene
中文别名	丁二烯 1，3-丁二烯
英文别名	butadiene EINECS 203-450-8 a,g-Butadiene cis-butadiene MFCD00008659 divinyl trans-butadiene α,γ-Butadiene 1,3-BUTADIENE Butadiene, 1,3- α-γ-butadiene buta-1,3-diene

密度	0.6±0.1 g/cm3
沸点	-4.4±0.0 °C at 760 mmHg
熔点	−109 °C(lit.)
分子式	C₄H₆
分子量	54.090
闪点	-76.1±0.0 °C
精确质量	54.046951
LogP	1.86
外观性状	无色气体(压缩液化气体)
蒸汽密度	1.9 (15 °C, vs air)
蒸汽压	2101.8±0.0 mmHg at 25°C
折射率	1.389
储存条件	储存注意事项储存于阴凉、通风的易燃气体专用库房。远离火种、热源。库温不宜超过30℃。应与氧化剂、卤素等分开存放，切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备。
稳定性	1.本品毒性较小，其毒性与乙烯类似，但对皮肤和黏膜的刺激较强，高浓度时有麻醉作用。动物吸入0.67%浓度的丁二烯，每天7.5小时，经8个月，除少数例外，一般对生长和健康无妨碍。工作场所最高容许浓度为2200mg/m3。液态丁二烯因低温可造成冻伤。生产设备应密封，严防跑、冒、滴、漏。防火、防热。 2.极易燃烧。相对无毒，疑为致癌物质，对呼吸道有强烈的刺激作用。易聚合，应避免聚合引发剂。实验室中的1,3-丁二烯是直接冷凝气体到容器中或在反应容器中形成该气体的饱和溶液来使用的。在更高温度的反应中，为防止1,3-丁二烯的泄漏要用铅封的试管。 3.稳定性稳定 4.禁配物强氧化剂、卤素、氧、铜合金、酸类 5.避免接触的条件受热、光照 6.聚合危害聚合
凝固点	-108.91℃
分子结构	1、摩尔折射率：20.03 2、摩尔体积（cm³/mol）：84.7 3、等张比容（90.2K）：169.2 4、表面张力（dyne/cm）：15.9 5、介电常数：2.26 6、偶极距（10^-24cm³）： 7、极化率：7.94
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:0 4.可旋转化学键数量:1 5.互变异构体数量:无 6.拓扑分子极性表面积0 7.重原子数量:4 8.表面电荷:0 9.复杂度:21 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：轻微芳香味无色气体。 2.熔点（℃）：-108.9 3.沸点（℃）：-4.4 4.相对密度（水=1）：0.62 5.相对蒸气密度（空气=1）：1.87 6.饱和蒸气压（kPa）：245.27（21℃） 7.燃烧热（kJ/mol）：-2541.0 8.临界温度（℃）：161.8 9.临界压力（MPa）：4.33 10.辛醇/水分配系数：1.99 11.闪点（℃）：-76 12.引燃温度（℃）：415 13.爆炸上限（%）：16.3 14.爆炸下限（%）：1.1 15.溶解性：不溶于水，溶于丙酮、苯、乙酸、酯等多数有机溶剂。 16.溶度参数(J·cm^-3)^0.5：15.607 17.van der Waals面积（cm²·mol^-1）：5.880×10⁹ 18.van der Waals体积（cm³·mol^-1）：40.820 19.临界密度（g·cm^-3）：0.245 20.临界体积（cm³·mol^-1）：221 21.临界压缩因子：0.270 22.偏心因子：0.193 23.气相标准燃烧热(焓)(kJ·mol^-1)：-2541.49 24.气相标准声称热(焓)( kJ·mol^-1)：110.0 25.相标准熵(J·mol^-1·K^-1) ：278.78 26.气相标准生成自由能( kJ·mol^-1)：150.6 27.气相标准热熔(J·mol^-1·K^-1)：79.88 28.液相标准燃烧热(焓)(kJ·mol^-1)：-2519.4 29.液相标准声称热(焓)( kJ·mol^-1)：87.9 30.液相标准熵(J·mol^-1·K^-1) ：199.07 31.液相标准生成自由能( kJ·mol^-1)：152.13 32.液相标准热熔(J·mol^-1·K^-1)：123.65

国标编号:	21022
ＣＡＳ:	106-99-0
中文名称:	1，3-丁二烯
英文名称:	1,3-butadiene
别名:	联乙烯
分子式:	C₄H₆；CH₂CHCHCH₂
分子量:	54.09
熔点:	-108.9℃ 沸点：-4.5?
密度:	相对密度(水=1)0.62；
蒸汽压:	-78℃
溶解性:	溶于丙酮、苯、乙酸、酯等多数有机溶剂
稳定性:	稳定
外观与性状:	无色无臭气体
危险标记:	4(易燃气体)
用途:	用于合成橡胶ABS树酯、酸酐等

2.对环境的影响:
一、健康危害
侵入途径：吸入。
健康危害：本品具有麻醉和刺激作用。
二、毒理学资料及环境行为

毒性：属低毒类。
急性毒性：LD ₅₀5480mg/kg(大鼠经口)；LC ₅₀285000mg/m ³，4小时(大鼠吸入)；人吸入1%，轻度反应、头痛、口干、嗜睡等；人吸入17.6g/m ³×8小时，上呼吸道刺激反应；人吸入11g/m ³×6小时，眼粘膜轻度刺激。
亚急性和慢性毒性：大鼠吸入30mg/m ³，81天，造血功能亢进，心肌和肾脏有轻度退行性变。
致突变性：微生物致突变性：鼠伤寒沙门氏菌2pph。
生殖毒性：大鼠吸入最低中毒浓度(TCL ₀)：8000ppm(6小时)，(孕后6～15天)，对胎鼠骨骼、肌肉有影响。
危险特性：易燃，与空气混合能形成爆炸性混合物。接触热、火星、火焰或氧化剂易燃烧爆炸。若遇高热，可发生聚合反应，放出大量热量而引起容器破裂和爆炸事故。气体比空气重，能在较低处扩散到相当远的地方，遇明火会引着回燃。
燃烧(分解)产物：一氧化碳、二氧化碳。

3.现场应急监测方法:

便携式气相色谱法

4.实验室监测方法:

气相色谱法《空气中有害物的测定方法》(第二版)，杭士平主编

5.环境标准:

中国(TJ36-79)	车间空气中有害物质的最高容许浓度	100mg/m³
前苏联(1977)	居民区大气中有害物最大允许浓度	3mg/m³(最大值) 1mg/m³(昼夜均值)
前苏联(1975)	水体中有害物质最高允许浓度	0.05mg/L
	嗅觉阈浓度	0.38mg/m³

6.应急处理处置方法:
一、泄漏应急处理
迅速撤离泄漏污染区人员至上风处，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿消防防护服。尽可能切断泄漏源。用工业覆盖层或吸附/吸收剂盖住泄漏点附近的下水道等地方，防止气体进入。合理通风，加速扩散。喷雾状水稀释、溶解。构筑围堤或挖坑收容产生的大量废水。如有可能，将漏出气用排风机送至空旷地方或装设适当喷头烧掉。漏气容器要妥善处理，修复、检验后再用。
废弃物处置方法：用焚烧法。
二、防护措施
呼吸系统防护：一般不需要特殊防护，高浓度接触时可佩带自吸过滤式防毒面具(半面罩)。
眼睛防护：必要时，戴化学安全防护眼镜。
身体防护：穿防静电工作服。
手防护：戴一般作业防护手套。
其它：工作现场严禁吸烟。避免长期反复接触。进入罐、限制性空间或其它高浓度区作业，须有人监护。
三、急救措施
皮肤接触：立即脱去被污染的衣着，用大量流动清水冲洗，至少15分钟。就医。
眼睛接触：提起眼睑，用流动清水或生理盐水彻底冲洗。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
灭火方法：切断气源。若不能立即切断气源，则不允许熄灭正在燃烧的气体。喷水冷却容器，可能的话将容器从火场移至空旷处。灭火剂：雾状水、泡沫、二氧化碳、干粉。

毒理学数据:

1.急性毒性

LD50：5480mg/kg（大鼠经口）；3210mg/kg（小鼠经口）

LC50：285000mg/m³（大鼠吸入，4h）；259ppm（小鼠吸入，7h）

2.刺激性暂无资料

3.亚急性与慢性毒性家兔，用20%~25%的麻醉浓度，每天麻醉8~10min，每周4~5次，2~3周，未发现病变。小鼠吸入30mg/m³,81d出现造血功能亢进，吞噬反应增强，心肌和肾脏轻度退化变性等。

4.致突变性微生物致突变性：鼠伤寒沙门菌2%。姐妹染色单体交换：人淋巴细胞500μmol/L。

5.致畸性大鼠孕后6~15d吸入最低中毒剂量（TCLo）8000ppm（6h），致肌肉骨骼系统发育畸形。

6.致癌性 IARC：G2A，可能人类致癌物。

7.其他大鼠吸入最低中毒浓度（TCLo）：8000ppm（6h）（孕后6~15d），对胎鼠骨骼、肌肉有影响。

生态学数据:

1.生态毒性

LC50：25mg/L（96h）（蓝鳃太阳鱼）；50mg/L（96h）（黑头呆鱼）；21mg/L（96h）（斑猫鲿）；22mg/L（96h）（虹鳟鱼）

EC50：25mg/L（96h）（水蚤）

2.生物降解性

好氧生物降解性（h）：168~672

厌氧生物降解性（h）：672~2688

3.非生物降解性

水中光氧化半衰期（h）：1200~48000

空气中光氧化半衰期（h）：0.76~7.8

4.生物富集性 BCF：19.1

5.其他有害作用该物质对环境有危害，对鱼类应给予特别注意。还应特别注意对地表水、土壤、大气和饮用水的污染。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI9275000

CHEMICAL NAME :: 1,3-Butadiene

CAS REGISTRY NUMBER :: 106-99-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 83

MOLECULAR FORMULA :: C4-H6

MOLECULAR WEIGHT :: 54.10

WISWESSER LINE NOTATION :: 1U2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2000 ppm/7H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 8000 ppm

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - cough

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 285 gm/m3/4H

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 pph/23M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/6H/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/m3/4H/17W-I

TOXIC EFFECTS :: Blood - leukopenia Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ppm/6H/14W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ppm/6H/6W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ppm/6H/24W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/m3/4H/17W-I

TOXIC EFFECTS :: Immunological Including Allergic - decrease in cellular immune response Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 625 ppm/6H/61W

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Cardiac - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 ppm/6H/13W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Cardiac - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - thyroid tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/6H/15W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ppm/40W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 ppm/6H/65W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Eye) - tumors Cardiac - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 8000 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ppm/6H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Mutation in mammalian somatic cells

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Heritable translocation test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 263,47,1991 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4.4 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,155,1986 IARC Cancer Review:Animal SUFFICENT EVIDENCE IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,237,1992 IARC Cancer Review:Human LIMITED EVIDENC IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,237,1992 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,155,1986 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,237,1992 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1000 ppm (2200 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,28,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 10 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 10 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 50 ppm (73 mg/m3);Carcinogen JAN 1993 OEL-FRANCE:TWA 10 ppm (36 mg/m3) JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (110 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (2200 mg/m3) JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:STEL 100 mg/m3 JAN 1993 OEL-SWEDEN:TWA 10 ppm (20 mg/m3);STEL 20 ppm (40 mg/m3);Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (11 mg/m3);Carcinogen JAN 1993 OEL-TURKEY:TWA 1000 ppm (2200 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (22 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,3-BUTADIENE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 13410 No. of Facilities: 3086 (estimated) No. of Industries: 26 No. of Occupations: 71 No. of Employees: 66326 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 13410 No. of Facilities: 2201 (estimated) No. of Industries: 20 No. of Occupations: 34 No. of Employees: 51971 (estimated) No. of Female Employees: 1410 (estimated)

符号	GHS02, GHS08
信号词	Danger
危害声明	H220-H280-H340-H350
警示性声明	P201-P210-P308 + P313-P410 + P403
个人防护装备	Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
危害码 (欧洲)	F+,T,F,N
风险声明 (欧洲)	R12;R45
安全声明 (欧洲)	S53-S45-S62-S46-S36/37-S26-S61-S33-S16
危险品运输编码	UN 1010 2.1
WGK德国	2
RTECS号	EI9275000
危险类别	2.1

上游产品 8
106-98-9 75-09-2 2622-05-1 5954-75-6
107-01-7 54509-73-8 592-46-1 590-18-1
下游产品 10
1072-96-4 105191-72-8 108451-43-0 108451-44-1
109802-71-3 52636-83-6 41097-72-7 108144-23-6
10437-78-2 101774-07-6

1.乙醇法　以乙醇为原料，以氧化镁二氧化硅为主催化剂，加入活性添加剂，在360～370℃下，催化脱氢和脱水，生成丁二烯。　

2.抽提法　乙烯裂解装置副产C4馏分，用溶剂抽提法提取丁二烯，依采用的溶剂不同，可分为乙腈抽提法和犖，N-二甲基甲酰胺抽提法。(1)乙腈抽提法　以乙腈为萃取剂。将乙烯裂解装置副产的C4馏分送入丁二烯萃取精馏塔，顶部加入乙腈，丁烯及少量丁烷从塔顶排出；丁二烯、炔烃和乙腈进入第一解吸塔，乙腈被解吸出来，并返回萃取精馏塔。丁二烯和炔烃进入第二萃取塔，塔顶加入乙腈，丁二烯从塔顶出来，进入水洗塔，再经精馏脱水得聚合级丁二烯。(2)N,N-二甲基甲酰胺抽提法　以犖，N-二甲基甲酰胺为萃取剂。C4馏分二次萃取，二次精馏，制取合格的丁二烯产品。第一次萃取脱除比丁二烯难溶于犖，N-二甲基甲酰胺的杂质，如丁烯、丁烷；第二次萃取脱除比丁二烯易溶于N，N-二甲基甲酰胺的杂质，如乙烯基乙炔。第一次精馏脱除比丁二烯轻的组分，如甲基乙炔；第二次精馏脱除比丁二烯重的组分，如顺2-丁烯、1,2-丁二烯、C5馏分及高沸点物，最后得到99.5%以上的1,3-丁二烯成品。

106-99-0	25339-57-5
77-79-2	9003-17-2
40022-03-5	129288-65-9
685-63-2	126-99-8
87-68-3	298-18-0