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298-59-9

298-59-9结构式
298-59-9结构式

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中文名 盐酸哌甲酯
英文名 methylphenidate hydrochloride
中文别名 alpha-苯基-2-哌啶乙酸甲酯盐酸盐
英文别名 Methyl 2-phenyl-2-(piperidin-2-yl)acetate hydrochloride
Methyl (2S)-phenyl[(2S)-2-piperidinyl]acetate hydrochloride (1:1)
Ciba 4311b
Concerta
Methylphenidate hydrochloride
EINECS 206-065-3
Methyl phenyl(2-piperidinyl)acetate hydrochloride (1:1)
2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride (1:1)
Metadate
Methyl a-Phenyl-a-(2-piperidyl)acetate Hydrochloride
METHYLPHENIDATE.HCl
2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride, (R*,R*)- (±)-
a-Phenyl-a-(2-piperidyl)acetic Acid Methyl Ester Hydrochloride
2-Piperidineacetic acid, α-phenyl-, methyl ester, (αS,2S)-, hydrochloride (1:1)
a-Phenyl-2-piperidineacetic Acid Methyl Ester Hydrochloride
Methyl α-phenyl-2-piperidineacetate hydrochloride
Methyl phenyl(piperidin-2-yl)acetate hydrochloride (1:1)
methylphenidate HCl
MFCD00058191
2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride
Ritalin hydrochloride
沸点 327.6ºC at 760 mmHg
熔点 224 - 226ºC
分子式 C14H20ClNO2
分子量 269.767
闪点 152ºC
精确质量 269.118256
PSA 38.33000
LogP 3.21610
外观性状 白色结晶粉末
蒸汽压 0.000199mmHg at 25°C
折射率 1.523
储存条件 Store at RT
稳定性 Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates.

Section 1. Chemical Product and Company Identification
Methylphenidate Hydrochloride
Common Name/
Trade Name
Manufacturer
Commercial Name(s)
Synonym
Chemical Name
Chemical Family
Methylphenidate Hydrochloride

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Cold water may be used.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature 550°C (1022°F)
Flash PointsNot available.
Flammable LimitsNot available.
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various SubstancesNon-flammable in presence of open flames and sparks.
Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks.
of Various SubstancesNon-explosive in presence of shocks.
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks onAs with most organic solids, fire is possible at elevated temperatures
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
Hazardsexplosion hazard.

Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Methylphenidate Hydrochloride

Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable
respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep
away from incompatibles such as alkalis.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Solid.OdorOdorless.
Not available.
Taste
Molecular Weight269.77 g/mole
White.
Color
Not available.
pH (1% soln/water)
Boiling PointNot available.
Melting Point224°C (435.2°F)
Critical TemperatureNot available.
Specific GravityNot available.
Not applicable.
Vapor Pressure
Vapor DensityNot available.
Not available.
Volatility
Odor ThresholdNot available.
Water/Oil Dist. Coeff.Not available.
Ionicity (in Water)Not available.
Dispersion PropertiesSee solubility in water, methanol.
SolubilityEasily soluble in cold water, methanol.
Very slightly soluble in acetone.
Soluble in alcohol.
Slightly soluble in Chloroform.
Methylphenidate Hydrochloride

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Heat, incompatible materials
Conditions of Instability
Reactive with alkalis.
Incompatibility with various
substances
CorrosivityNot available.
Special Remarks onNot available.
Reactivity
Special Remarks onNot available.
Corrosivity
PolymerizationWill not occur.

Section 11. Toxicological Information
Routes of EntryAbsorbed through skin. Inhalation. Ingestion.
Toxicity to AnimalsAcute oral toxicity (LD50): 60 mg/kg [Mouse].
Chronic Effects on Humans May cause damage to the following organs: cardiovascular system, central nervous system (CNS).
Other Toxic Effects onHazardous in case of ingestion, of inhalation.
HumansSlightly hazardous in case of skin contact (irritant, sensitizer, permeator).
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onMay cause cancer based on animal test data.
Chronic Effects on Humans
May affect genetic material (mutagenic)
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation. It may be absorbed through broken skin.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation and cause sneezing, coughing, hypersensitivity and other
symptoms similar to ingestion.
Ingestion: Harmful if swallowed. It is a narcotic. It may cause nausea, stomach pain, dry mouth, and vomiting. It
may affect behavior/central nervous system, cardiovascular system, urinary system, brain, liver, blood. Other
adverse health effects may include: fast heartbeat, heart palpitations, increased blood pressure, irregular heart
beat, bruising, skin rash, fever, sweating, loss of appetite, uncontrolled movements, joint pain, nervousness,
dizziness, sleepiness, agitiation, insomnia, confusion, tremors, muscle twitching, delirium, hallucinations, sense of
well-being, convulsions possibly followed by coma.
Chronic Potential Health Effects:
Skin: Repeated or prolonged skin contact may cause hypersensitivity.
Ingestion: Repeated or prolonged ingestion may cause habituation or addiction. Prolonged or repeated ingestion
may also cause sensitization (hypersensitivity) and develop skin rashes, coughs, stuffy nose, asthma, and other
allergic reactions. Hypersensitivity may develop immediately after contact or after years of exposure. Prolonged
ingestion may also cause weight loss.
Medical conditions aggravated by exposure: severe anxiety, tension or agitation, severe depression, glaucoma,
motor tics, Tourette's Syndrome, and high blood pressure.
Methylphenidate Hydrochloride

Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The products of degradation are less toxic than the product itself.
Toxicity of the Products
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC)R22- Harmful if swallowed.S2- Keep out of the reach of children.
S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.)2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
Methylphenidate Hydrochloride
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Methylphenidate Hydrochloride
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM3850000
CHEMICAL NAME :
2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride
CAS REGISTRY NUMBER :
298-59-9
LAST UPDATED :
199712
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C14-H19-N-O2.Cl-H
MOLECULAR WEIGHT :
269.80
WISWESSER LINE NOTATION :
T6MTJ BYR&VO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
32 mg/kg/6W-I
TOXIC EFFECTS :
Behavioral - toxic psychosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
96500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6370 mg/kg/13W-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5320 mg/kg/14D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6370 mg/kg/13W-C
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/kg/14D-C
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18250 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
702 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6175 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 697 (estimated) No. of Female Employees: 366 (estimated)

符号 GHS07 GHS08
GHS07, GHS08
信号词 Danger
危害声明 H302-H334
警示性声明 P261-P342 + P311
个人防护装备 dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲) Xn: Harmful;
风险声明 (欧洲) R22;R42
安全声明 (欧洲) 22-26-36
危险品运输编码 UN 3249
WGK德国 3
RTECS号 TM3850000
包装等级 III
危险类别 6.1(b)
海关编码 2933399090

~58%

298-59-9结构式

298-59-9

文献:US2004/176412 A1, ; Page/Page column 5-6 ;
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海关编码 2933399090
中文概述 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%